FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035591710> ?p ?o ?g. }

• W3035591710 abstract "Shikonin is a natural naphthoquinone compound and has demonstrated potent anti-cancer activities; however, the underlying molecular mechanisms remained elusive. Here we report that Shikonin inhibited the growth of a wide range of human cancer cell lines, illustrating a broad anticancer effect. Mechanistically, we show that Shikonin arrested the cell cycle at the G2/M phase, inhibited the ERK-dependent cell growth signal, and induced cell death in both P53 wild type and mutant cancer cells, which collectively contributed to the growth inhibitory effect of Shikonin. A pan-apoptosis inhibitor largely suppressed Shikonin-induced cell death, suggesting an important role of apoptosis in this process. Intriguingly, Shikonin also activated autophagy and inhibition of autophagy by depleting critical autophagic genes further increased Shikonin-induced cell death, indicating a protective role of autophagy. In uncovering the molecular mechanisms underlying these effects of Shikonin, we found that Shikonin induced a robust upregulation of P21 independent of the P53 status, upregulated autophagy genes, as well as inhibited expression of genes required for cell growth. Using mouse tumor models, we confirmed the strong anticancer effect of Shikonin in vivo. Together, our data reveal a broad range of pharmacological functions of Shikonin, involving simultaneous growth inhibition, cell cycle arrest, autophagy activation and apoptosis induction through regulating expression of critical genes involved in these pathways. Our study may facilitate the development of Shikonin in cancer therapy as a single agent or in combination with other anticancer therapies." @default.
• W3035591710 created "2020-06-19" @default.
• W3035591710 creator A5044291823 @default.
• W3035591710 creator A5044417450 @default.
• W3035591710 creator A5046418414 @default.
• W3035591710 creator A5057234380 @default.
• W3035591710 creator A5060106231 @default.
• W3035591710 creator A5067368737 @default.
• W3035591710 creator A5073277004 @default.
• W3035591710 date "2020-06-09" @default.
• W3035591710 modified "2023-10-12" @default.
• W3035591710 title "Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction" @default.
• W3035591710 cites W1483925515 @default.
• W3035591710 cites W1523693806 @default.
• W3035591710 cites W1916777863 @default.
• W3035591710 cites W1941453499 @default.
• W3035591710 cites W1964257510 @default.
• W3035591710 cites W1964893337 @default.
• W3035591710 cites W1985124617 @default.
• W3035591710 cites W1991418047 @default.
• W3035591710 cites W1995709551 @default.
• W3035591710 cites W2007010211 @default.
• W3035591710 cites W2009925740 @default.
• W3035591710 cites W2014958464 @default.
• W3035591710 cites W2026799139 @default.
• W3035591710 cites W2030945380 @default.
• W3035591710 cites W2036422868 @default.
• W3035591710 cites W2048030072 @default.
• W3035591710 cites W2051524616 @default.
• W3035591710 cites W2059520792 @default.
• W3035591710 cites W2064096260 @default.
• W3035591710 cites W2064746187 @default.
• W3035591710 cites W2070061120 @default.
• W3035591710 cites W2079931546 @default.
• W3035591710 cites W2081145901 @default.
• W3035591710 cites W2109034822 @default.
• W3035591710 cites W2110400866 @default.
• W3035591710 cites W2137979644 @default.
• W3035591710 cites W2143089914 @default.
• W3035591710 cites W2157045574 @default.
• W3035591710 cites W2162262059 @default.
• W3035591710 cites W2231687352 @default.
• W3035591710 cites W2333665368 @default.
• W3035591710 cites W2343423203 @default.
• W3035591710 cites W2395035021 @default.
• W3035591710 cites W2617642067 @default.
• W3035591710 cites W2727192809 @default.
• W3035591710 cites W2731165670 @default.
• W3035591710 cites W2734735303 @default.
• W3035591710 cites W2752942423 @default.
• W3035591710 cites W2765725591 @default.
• W3035591710 cites W2766675128 @default.
• W3035591710 cites W2768044666 @default.
• W3035591710 cites W2768652341 @default.
• W3035591710 cites W2786248310 @default.
• W3035591710 cites W2794471978 @default.
• W3035591710 cites W2801832456 @default.
• W3035591710 cites W2801951868 @default.
• W3035591710 cites W2806738135 @default.
• W3035591710 cites W2807096162 @default.
• W3035591710 cites W2807261444 @default.
• W3035591710 cites W2809389975 @default.
• W3035591710 cites W2921533346 @default.
• W3035591710 cites W2979481633 @default.
• W3035591710 cites W4245361947 @default.
• W3035591710 cites W969461070 @default.
• W3035591710 doi "https://doi.org/10.3389/fphar.2020.00861" @default.
• W3035591710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7296065" @default.
• W3035591710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32581812" @default.
• W3035591710 hasPublicationYear "2020" @default.
• W3035591710 type Work @default.
• W3035591710 sameAs 3035591710 @default.
• W3035591710 citedByCount "31" @default.
• W3035591710 countsByYear W30355917102020 @default.
• W3035591710 countsByYear W30355917102021 @default.
• W3035591710 countsByYear W30355917102022 @default.
• W3035591710 countsByYear W30355917102023 @default.
• W3035591710 crossrefType "journal-article" @default.
• W3035591710 hasAuthorship W3035591710A5044291823 @default.
• W3035591710 hasAuthorship W3035591710A5044417450 @default.
• W3035591710 hasAuthorship W3035591710A5046418414 @default.
• W3035591710 hasAuthorship W3035591710A5057234380 @default.
• W3035591710 hasAuthorship W3035591710A5060106231 @default.
• W3035591710 hasAuthorship W3035591710A5067368737 @default.
• W3035591710 hasAuthorship W3035591710A5073277004 @default.
• W3035591710 hasBestOaLocation W30355917101 @default.
• W3035591710 hasConcept C104317684 @default.
• W3035591710 hasConcept C105696609 @default.
• W3035591710 hasConcept C121608353 @default.
• W3035591710 hasConcept C127561419 @default.
• W3035591710 hasConcept C185592680 @default.
• W3035591710 hasConcept C190283241 @default.
• W3035591710 hasConcept C203522944 @default.
• W3035591710 hasConcept C29537977 @default.
• W3035591710 hasConcept C31573885 @default.
• W3035591710 hasConcept C502942594 @default.
• W3035591710 hasConcept C54355233 @default.
• W3035591710 hasConcept C55493867 @default.
• W3035591710 hasConcept C57074206 @default.
• W3035591710 hasConcept C62112901 @default.

• next