Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035594055> ?p ?o ?g. }
- W3035594055 abstract "Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is termed clonal hematopoiesis of indeterminate potential (CHIP) and is associated with adverse outcomes. Targeted sequencing of the stem cell product from 629 MM patients treated by ASCT at the Dana-Farber Cancer Institute (2003-2011) detects CHIP in 136/629 patients (21.6%). The most commonly mutated genes are DNMT3A, TET2, TP53, ASXL1 and PPM1D. Twenty-one from fifty-six patients (3.3%) receiving first-line IMiD maintenance develop a therapy-related myeloid neoplasm (TMN). However, regardless of CHIP status, the use of IMiD maintenance associates with improved PFS and OS. In those not receiving IMiD maintenance, CHIP is associated with decreased overall survival (OS) (HR:1.34, p = 0.02) and progression free survival (PFS) (HR:1.45, p < 0.001) due to an increase in MM progression." @default.
- W3035594055 created "2020-06-19" @default.
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- W3035594055 date "2020-06-12" @default.
- W3035594055 modified "2023-10-14" @default.
- W3035594055 title "Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant" @default.
- W3035594055 cites W1895753987 @default.
- W3035594055 cites W1985823023 @default.
- W3035594055 cites W1992826811 @default.
- W3035594055 cites W1999702620 @default.
- W3035594055 cites W2021341670 @default.
- W3035594055 cites W2029053551 @default.
- W3035594055 cites W2059581635 @default.
- W3035594055 cites W2065121554 @default.
- W3035594055 cites W2075877031 @default.
- W3035594055 cites W2096746187 @default.
- W3035594055 cites W2099328768 @default.
- W3035594055 cites W2101035019 @default.
- W3035594055 cites W2104195581 @default.
- W3035594055 cites W2107356675 @default.
- W3035594055 cites W2114031931 @default.
- W3035594055 cites W2119180969 @default.
- W3035594055 cites W2120474651 @default.
- W3035594055 cites W2125721471 @default.
- W3035594055 cites W2126298009 @default.
- W3035594055 cites W2126816979 @default.
- W3035594055 cites W2128084036 @default.
- W3035594055 cites W2131256397 @default.
- W3035594055 cites W2135052052 @default.
- W3035594055 cites W2138601221 @default.
- W3035594055 cites W2146290346 @default.
- W3035594055 cites W2149858388 @default.
- W3035594055 cites W2168133698 @default.
- W3035594055 cites W2169846247 @default.
- W3035594055 cites W2170490448 @default.
- W3035594055 cites W2256016639 @default.
- W3035594055 cites W2336403630 @default.
- W3035594055 cites W2417483443 @default.
- W3035594055 cites W2511116391 @default.
- W3035594055 cites W2557652172 @default.
- W3035594055 cites W2557981253 @default.
- W3035594055 cites W2558446569 @default.
- W3035594055 cites W2565836268 @default.
- W3035594055 cites W2574119868 @default.
- W3035594055 cites W2578808037 @default.
- W3035594055 cites W2587066646 @default.
- W3035594055 cites W2604776612 @default.
- W3035594055 cites W2612571615 @default.
- W3035594055 cites W2628145035 @default.
- W3035594055 cites W2737964630 @default.
- W3035594055 cites W2745259295 @default.
- W3035594055 cites W2765435739 @default.
- W3035594055 cites W2777262489 @default.
- W3035594055 cites W2783064655 @default.
- W3035594055 cites W2800112295 @default.
- W3035594055 cites W2805293188 @default.
- W3035594055 cites W2810683705 @default.
- W3035594055 cites W2830196912 @default.
- W3035594055 cites W2883213242 @default.
- W3035594055 cites W2899272142 @default.
- W3035594055 cites W2909552152 @default.
- W3035594055 cites W2937974806 @default.
- W3035594055 cites W2968120913 @default.