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- W3035600038 endingPage "4271" @default.
- W3035600038 startingPage "4271" @default.
- W3035600038 abstract "Epithelial–mesenchymal transition (EMT) and endothelial–mesenchymal transition (EndMT) are physiological processes required for normal embryogenesis. However, these processes can be hijacked in pathological conditions to facilitate tissue fibrosis and cancer metastasis. In the eye, EMT and EndMT play key roles in the pathogenesis of subretinal fibrosis, the end-stage of age-related macular degeneration (AMD) that leads to profound and permanent vision loss. Predominant in subretinal fibrotic lesions are matrix-producing mesenchymal cells believed to originate from the retinal pigment epithelium (RPE) and/or choroidal endothelial cells (CECs) through EMT and EndMT, respectively. Recent evidence suggests that EMT of RPE may also be implicated during the early stages of AMD. Transforming growth factor-beta (TGFβ) is a key cytokine orchestrating both EMT and EndMT. Investigations in the molecular mechanisms underpinning EMT and EndMT in AMD have implicated a myriad of contributing factors including signaling pathways, extracellular matrix remodelling, oxidative stress, inflammation, autophagy, metabolism and mitochondrial dysfunction. Questions arise as to differences in the mesenchymal cells derived from these two processes and their distinct mechanistic contributions to the pathogenesis of AMD. Detailed discussion on the AMD microenvironment highlights the synergistic interactions between RPE and CECs that may augment the EMT and EndMT processes in vivo. Understanding the differential regulatory networks of EMT and EndMT and their contributions to both the dry and wet forms of AMD can aid the development of therapeutic strategies targeting both RPE and CECs to potentially reverse the aberrant cellular transdifferentiation processes, regenerate the retina and thus restore vision." @default.
- W3035600038 created "2020-06-19" @default.
- W3035600038 creator A5005938951 @default.
- W3035600038 creator A5074834105 @default.
- W3035600038 creator A5090986032 @default.
- W3035600038 date "2020-06-16" @default.
- W3035600038 modified "2023-10-11" @default.
- W3035600038 title "EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration" @default.
- W3035600038 cites W130218930 @default.
- W3035600038 cites W1484220887 @default.
- W3035600038 cites W1485133278 @default.
- W3035600038 cites W1571263028 @default.
- W3035600038 cites W1575754639 @default.
- W3035600038 cites W1580190537 @default.
- W3035600038 cites W1585035603 @default.
- W3035600038 cites W1608040782 @default.
- W3035600038 cites W1883306593 @default.
- W3035600038 cites W1955438350 @default.
- W3035600038 cites W1960434785 @default.
- W3035600038 cites W1965404473 @default.
- W3035600038 cites W1966857167 @default.
- W3035600038 cites W1968114204 @default.
- W3035600038 cites W1969737403 @default.
- W3035600038 cites W1973207504 @default.
- W3035600038 cites W1974046548 @default.
- W3035600038 cites W1978791916 @default.
- W3035600038 cites W1980059877 @default.
- W3035600038 cites W1980954887 @default.
- W3035600038 cites W1981158116 @default.
- W3035600038 cites W1981186447 @default.
- W3035600038 cites W1988201752 @default.
- W3035600038 cites W1991955057 @default.
- W3035600038 cites W1994133882 @default.
- W3035600038 cites W1995693160 @default.
- W3035600038 cites W1995732106 @default.
- W3035600038 cites W1996821302 @default.
- W3035600038 cites W1996959663 @default.
- W3035600038 cites W1998638590 @default.
- W3035600038 cites W2004291269 @default.
- W3035600038 cites W2004349871 @default.
- W3035600038 cites W2005487633 @default.
- W3035600038 cites W2006582405 @default.
- W3035600038 cites W2008965380 @default.
- W3035600038 cites W2011196230 @default.
- W3035600038 cites W2011204895 @default.
- W3035600038 cites W2012322597 @default.
- W3035600038 cites W2015418906 @default.
- W3035600038 cites W2017215522 @default.
- W3035600038 cites W2017565500 @default.
- W3035600038 cites W2023213297 @default.
- W3035600038 cites W2024688714 @default.
- W3035600038 cites W2024728199 @default.
- W3035600038 cites W2030838650 @default.
- W3035600038 cites W2032749652 @default.
- W3035600038 cites W2033414925 @default.
- W3035600038 cites W2035310463 @default.
- W3035600038 cites W2038916605 @default.
- W3035600038 cites W2039676145 @default.
- W3035600038 cites W2040385741 @default.
- W3035600038 cites W2043640009 @default.
- W3035600038 cites W2044563310 @default.
- W3035600038 cites W2044759195 @default.
- W3035600038 cites W2045390177 @default.
- W3035600038 cites W2045731328 @default.
- W3035600038 cites W2045992045 @default.
- W3035600038 cites W2048107972 @default.
- W3035600038 cites W2049669592 @default.
- W3035600038 cites W2051696368 @default.
- W3035600038 cites W2051812986 @default.
- W3035600038 cites W2055803933 @default.
- W3035600038 cites W2056044648 @default.
- W3035600038 cites W2057836285 @default.
- W3035600038 cites W2057847545 @default.
- W3035600038 cites W2057962872 @default.
- W3035600038 cites W2058108015 @default.
- W3035600038 cites W2059563381 @default.
- W3035600038 cites W2060198097 @default.
- W3035600038 cites W2063200478 @default.
- W3035600038 cites W2066040738 @default.
- W3035600038 cites W2066507973 @default.
- W3035600038 cites W2066593135 @default.
- W3035600038 cites W2067238776 @default.
- W3035600038 cites W2068800170 @default.
- W3035600038 cites W2071601082 @default.
- W3035600038 cites W2071787763 @default.
- W3035600038 cites W2076151830 @default.
- W3035600038 cites W2076270591 @default.
- W3035600038 cites W2077880960 @default.
- W3035600038 cites W2085433420 @default.
- W3035600038 cites W2086065725 @default.
- W3035600038 cites W2086929648 @default.
- W3035600038 cites W2087352632 @default.
- W3035600038 cites W2087766778 @default.
- W3035600038 cites W2089026133 @default.
- W3035600038 cites W2091434242 @default.
- W3035600038 cites W2091815327 @default.
- W3035600038 cites W2092638574 @default.
- W3035600038 cites W2093910316 @default.