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• W3035622588 endingPage "101262" @default.
• W3035622588 startingPage "101262" @default.
• W3035622588 abstract "PhenolaTi is an advanced non-toxic anticancer chemotherapy; this inert bis(phenolato)bis(alkoxo) Ti(IV) complex demonstrates the intriguing combination of high and wide efficacy with no detected toxicity in animals. Here we unravel the cellular pathways involved in its mechanism of action by a first genome study on Ti(IV)-treated cells, using an attuned RNA sequencing-based available technology. First, phenolaTi induced apoptosis and cell-cycle arrest at the G2/M phase in MCF7 cells. Second, the transcriptome of the treated cells was analyzed, identifying alterations in pathways relating to protein translation, DNA damage, and mitochondrial eruption. Unlike for common metallodrugs, electrophoresis assay showed no inhibition of DNA polymerase activity. Reduced in vitro cytotoxicity with added endoplasmic reticulum (ER) stress inhibitor supported the ER as a putative cellular target. Altogether, this paper reveals a distinct ER-related mechanism by the Ti(IV) anticancer coordination complex, paving the way for wider applicability of related techniques in mechanistic analyses of metallodrugs." @default.
• W3035622588 created "2020-06-19" @default.
• W3035622588 creator A5021186029 @default.
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• W3035622588 date "2020-07-01" @default.
• W3035622588 modified "2023-09-27" @default.
• W3035622588 title "Titanium Tackles the Endoplasmic Reticulum: A First Genomic Study on a Titanium Anticancer Metallodrug" @default.
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• W3035622588 doi "https://doi.org/10.1016/j.isci.2020.101262" @default.
• W3035622588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7322074" @default.
• W3035622588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32585595" @default.
• W3035622588 hasPublicationYear "2020" @default.

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