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- W3035626072 endingPage "1789" @default.
- W3035626072 startingPage "1778" @default.
- W3035626072 abstract "Immune checkpoint inhibitors have emerged as a revolutionary treatment option for patients with various types of malignancy. Although these agents afford a significant improvement in outcomes for melanoma and other previously untreatable malignancies, their novel mechanism of action may predispose patients to immune‐related adverse effects (irAEs). In the tumour neoantigen environment, these irAEs are due to the activation of the immune system by the blockade of suppressive checkpoints, leading to increases in T‐cell activation and proliferation. IrAEs have been reported in almost any organ and at any point in time, even months to years after discontinuation of therapy. Certain populations with distinct physiological changes, genetic risk factors, and specific antigen exposures may be more highly predisposed to develop irAEs. This review discusses the incidence and mechanisms of irAEs and the relationship between host factors and irAE occurrence." @default.
- W3035626072 created "2020-06-19" @default.
- W3035626072 creator A5005483243 @default.
- W3035626072 creator A5006513734 @default.
- W3035626072 creator A5019401898 @default.
- W3035626072 creator A5025067315 @default.
- W3035626072 creator A5031188214 @default.
- W3035626072 creator A5080985934 @default.
- W3035626072 creator A5089113899 @default.
- W3035626072 date "2020-07-17" @default.
- W3035626072 modified "2023-10-16" @default.
- W3035626072 title "Evolving insights into the mechanisms of toxicity associated with immune checkpoint inhibitor therapy" @default.
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