FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035670785> ?p ?o ?g. }

• W3035670785 abstract "Maternal diabetes during pregnancy impacts offspring body composition and has been associated with greater offspring adiposity across the life course. However, the extent to which the relationship between maternal glycemia and offspring adiposity during later life is independent of neonatal adiposity is unclear. In a prospective study of 544 mother-child pairs in the Healthy Start Study, we estimated the total effect of maternal HbA1c on childhood fat mass (FM) %, and the direct effect independent of neonatal FM %. We measured maternal fasting HbA1c at a gestational age of 20-34 weeks, and offspring FM % using air displacement plethysmography at birth and during childhood (age 4-7 y). We used multivariable linear regression with HbA1c tertiles (T1 [reference], T2, T3) as the exposure, neonatal FM % as the mediator, and childhood FM % as the outcome. A counterfactual-based approach was used to estimate total and direct effects, while also accounting for exposure-mediator interaction. Covariates were maternal race, education, gestational weight gain and smoking, and offspring sex and age. The medians (interquartile ranges) of the HbA1c tertiles were T1: 4.80 (3.70, 4.90), T2: 5.05 (5.00, 5.10), and T3: 5.30 (5.20, 6.30). The estimated total effect on child FM % was 1.27 (95% CI: 0.00, 2.54) units higher for T2 vs. T1, and 1.53 (0.23, 2.82) units higher for T3 vs. T1 (P-trend=0.02). After adjusting for pre-pregnancy BMI, the total effect was 1.18 (-0.09, 2.44) and 1.31 (0.00, 2.62) units higher for T2 vs. T1 and T3 vs. T1, respectively (P-trend=0.04). The direct effect after accounting for neonatal FM % was slightly attenuated (T2 vs. T1: 1.14 [-0.11, 2.39], T3 vs. T1: 1.20 [-0.11, 2.51]; P-trend=0.07). Excluding women with gestational diabetes mellitus (n=27) did not substantially impact the results. Our data suggest that maternal glycemia during pregnancy, even within normal levels, may influence childhood adiposity through pathways that are in part mediated by programming of neonatal adiposity. Disclosure E.C. Francis: None. B. Ringham: None. D.H. Glueck: None. W. Perng: None. D. Dabelea: None. Funding National Institute of Diabetes and Digestive and Kidney Diseases (5R01DK076648-10)" @default.
• W3035670785 created "2020-06-19" @default.
• W3035670785 creator A5004823841 @default.
• W3035670785 creator A5033970059 @default.
• W3035670785 creator A5036408222 @default.
• W3035670785 creator A5041410391 @default.
• W3035670785 creator A5080949076 @default.
• W3035670785 date "2020-06-01" @default.
• W3035670785 modified "2023-09-26" @default.
• W3035670785 title "1245-P: Maternal HbA1c Is Related to Childhood Fat Mass and Only Partially Mediated by Neonatal Fat Mass" @default.
• W3035670785 doi "https://doi.org/10.2337/db20-1245-p" @default.
• W3035670785 hasPublicationYear "2020" @default.
• W3035670785 type Work @default.
• W3035670785 sameAs 3035670785 @default.
• W3035670785 citedByCount "0" @default.
• W3035670785 crossrefType "journal-article" @default.
• W3035670785 hasAuthorship W3035670785A5004823841 @default.
• W3035670785 hasAuthorship W3035670785A5033970059 @default.
• W3035670785 hasAuthorship W3035670785A5036408222 @default.
• W3035670785 hasAuthorship W3035670785A5041410391 @default.
• W3035670785 hasAuthorship W3035670785A5080949076 @default.
• W3035670785 hasConcept C112672928 @default.
• W3035670785 hasConcept C119060515 @default.
• W3035670785 hasConcept C126322002 @default.
• W3035670785 hasConcept C131872663 @default.
• W3035670785 hasConcept C134018914 @default.
• W3035670785 hasConcept C188816634 @default.
• W3035670785 hasConcept C2778376644 @default.
• W3035670785 hasConcept C2779234561 @default.
• W3035670785 hasConcept C2779434492 @default.
• W3035670785 hasConcept C2780221984 @default.
• W3035670785 hasConcept C46973012 @default.
• W3035670785 hasConcept C54355233 @default.
• W3035670785 hasConcept C66322754 @default.
• W3035670785 hasConcept C71924100 @default.
• W3035670785 hasConcept C86803240 @default.
• W3035670785 hasConceptScore W3035670785C112672928 @default.
• W3035670785 hasConceptScore W3035670785C119060515 @default.
• W3035670785 hasConceptScore W3035670785C126322002 @default.
• W3035670785 hasConceptScore W3035670785C131872663 @default.
• W3035670785 hasConceptScore W3035670785C134018914 @default.
• W3035670785 hasConceptScore W3035670785C188816634 @default.
• W3035670785 hasConceptScore W3035670785C2778376644 @default.
• W3035670785 hasConceptScore W3035670785C2779234561 @default.
• W3035670785 hasConceptScore W3035670785C2779434492 @default.
• W3035670785 hasConceptScore W3035670785C2780221984 @default.
• W3035670785 hasConceptScore W3035670785C46973012 @default.
• W3035670785 hasConceptScore W3035670785C54355233 @default.
• W3035670785 hasConceptScore W3035670785C66322754 @default.
• W3035670785 hasConceptScore W3035670785C71924100 @default.
• W3035670785 hasConceptScore W3035670785C86803240 @default.
• W3035670785 hasIssue "Supplement_1" @default.
• W3035670785 hasLocation W30356707851 @default.
• W3035670785 hasOpenAccess W3035670785 @default.
• W3035670785 hasPrimaryLocation W30356707851 @default.
• W3035670785 hasRelatedWork W1591616590 @default.
• W3035670785 hasRelatedWork W2009428258 @default.
• W3035670785 hasRelatedWork W2025565591 @default.
• W3035670785 hasRelatedWork W2064652474 @default.
• W3035670785 hasRelatedWork W2099257454 @default.
• W3035670785 hasRelatedWork W2110681150 @default.
• W3035670785 hasRelatedWork W2333891256 @default.
• W3035670785 hasRelatedWork W2555964298 @default.
• W3035670785 hasRelatedWork W3160140598 @default.
• W3035670785 hasRelatedWork W4239714589 @default.
• W3035670785 hasVolume "69" @default.
• W3035670785 isParatext "false" @default.
• W3035670785 isRetracted "false" @default.
• W3035670785 magId "3035670785" @default.
• W3035670785 workType "article" @default.