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• W3035671969 startingPage "503209" @default.
• W3035671969 abstract "We have measured the toxicity and genotoxicity of 2-methylfuran, which is formed in foods during thermal processing. The agent was administered by oral gavage to male Sprague-Dawley rats, daily for 28 days, before performing general toxicology analysis and the following genotoxicity tests: comet assay (peripheral blood, liver); Pig-a gene mutation assay (peripheral blood); micronucleus test (peripheral blood, bone marrow). Liver was the primary target organ; histological changes (oval cell hyperplasia) were observed but without significant changes in serum enzyme markers. For hepatotoxicity, the no-observed-adverse-effect level was 5 mg/kg bw/d. Histopathological changes were also seen in the bone marrow. Genotoxicity assays were uniformly negative." @default.
• W3035671969 created "2020-06-19" @default.
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• W3035671969 date "2020-06-01" @default.
• W3035671969 modified "2023-10-15" @default.
• W3035671969 title "2-Methylfuran: Toxicity and genotoxicity in male Sprague-Dawley rats" @default.
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• W3035671969 doi "https://doi.org/10.1016/j.mrgentox.2020.503209" @default.
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