Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035679306> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3035679306 endingPage "33" @default.
- W3035679306 startingPage "29" @default.
- W3035679306 abstract "COVID-19 is a highly contagious viral infection with high morbidity that is draining health resources. The biggest complication is pneumonia, which has a serious inflammatory component, with no standardized treatment. Low-dose radiation therapy (LD-RT) is non-invasive and has anti-inflammatory effects that can interfere with the inflammatory cascade, thus reducing the severity of associated cytokine release and might be useful in the treatment of respiratory complications caused by COVID-19.This multicentric prospective clinical trial seeks to evaluate the efficacy of bilateral lung LD-RT therapy as a treatment for interstitial pneumonia in patients with COVID-19 for improving respiratory function.This prospective study will have 2 phases: I) an exploratory phase enrolling 10 patients, which will assess the feasibility and efficacy of low-dose lung irradiation, evaluated according to an increase in the PaO2/FiO2 ratio of at least 20% at 48-72 h with respect to the pre-irradiation value. If a minimum efficiency of 30% of the patients is not achieved, the study will not be continued. II) Non-randomized comparative phase in two groups: a control group, which will only receive pharmacological treatment, and an experimental arm with pharmacological treatment and LD-RT. It will include 96 patients, the allocation will be 1: 2, that is, 32 in the control arm and 64 in the experimental arm. The primary end-point will be the efficacy of LD-RT in patients with COVID-19 pneumonia according to an improvement in PaO2/FiO2. Secondary objectives will include the safety of bilateral lung LD-RT, an improvement in the radiology image, overall mortality rates at 15 and 30 days after irradiation and characterizing anti-inflammatory mechanisms of LD-RT by measuring the level of expression of adhesion molecules, anti-inflammatory cytokines and oxidative stress mediators.Trial registration: ClinicalTrial.gov NCT-04380818 https://clinicaltrials.gov/ct2/show/NCT04380818?term=RADIOTHERAPY&cond=COVID&draw=2&rank=4." @default.
- W3035679306 created "2020-06-19" @default.
- W3035679306 creator A5008003556 @default.
- W3035679306 creator A5010862068 @default.
- W3035679306 creator A5024866723 @default.
- W3035679306 creator A5043305490 @default.
- W3035679306 creator A5043896678 @default.
- W3035679306 creator A5056339747 @default.
- W3035679306 creator A5064477696 @default.
- W3035679306 creator A5066068652 @default.
- W3035679306 creator A5088786528 @default.
- W3035679306 date "2020-09-01" @default.
- W3035679306 modified "2023-09-27" @default.
- W3035679306 title "Low dose anti-inflammatory radiotherapy for the treatment of pneumonia by covid-19: A proposal for a multi-centric prospective trial" @default.
- W3035679306 cites W159285725 @default.
- W3035679306 cites W159472353 @default.
- W3035679306 cites W1924146854 @default.
- W3035679306 cites W1975759795 @default.
- W3035679306 cites W1993215753 @default.
- W3035679306 cites W2105243377 @default.
- W3035679306 cites W2161685643 @default.
- W3035679306 cites W2587707936 @default.
- W3035679306 cites W2944641096 @default.
- W3035679306 cites W3007775116 @default.
- W3035679306 cites W3011976215 @default.
- W3035679306 cites W3012405893 @default.
- W3035679306 cites W3012655019 @default.
- W3035679306 cites W3013893688 @default.
- W3035679306 cites W3015096810 @default.
- W3035679306 cites W3016044084 @default.
- W3035679306 cites W3020740437 @default.
- W3035679306 cites W3023031064 @default.
- W3035679306 cites W49375470 @default.
- W3035679306 doi "https://doi.org/10.1016/j.ctro.2020.06.005" @default.
- W3035679306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7317159" @default.
- W3035679306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32613089" @default.
- W3035679306 hasPublicationYear "2020" @default.
- W3035679306 type Work @default.
- W3035679306 sameAs 3035679306 @default.
- W3035679306 citedByCount "15" @default.
- W3035679306 countsByYear W30356793062020 @default.
- W3035679306 countsByYear W30356793062021 @default.
- W3035679306 countsByYear W30356793062022 @default.
- W3035679306 countsByYear W30356793062023 @default.
- W3035679306 crossrefType "journal-article" @default.
- W3035679306 hasAuthorship W3035679306A5008003556 @default.
- W3035679306 hasAuthorship W3035679306A5010862068 @default.
- W3035679306 hasAuthorship W3035679306A5024866723 @default.
- W3035679306 hasAuthorship W3035679306A5043305490 @default.
- W3035679306 hasAuthorship W3035679306A5043896678 @default.
- W3035679306 hasAuthorship W3035679306A5056339747 @default.
- W3035679306 hasAuthorship W3035679306A5064477696 @default.
- W3035679306 hasAuthorship W3035679306A5066068652 @default.
- W3035679306 hasAuthorship W3035679306A5088786528 @default.
- W3035679306 hasBestOaLocation W30356793061 @default.
- W3035679306 hasConcept C126322002 @default.
- W3035679306 hasConcept C168563851 @default.
- W3035679306 hasConcept C177713679 @default.
- W3035679306 hasConcept C188816634 @default.
- W3035679306 hasConcept C203092338 @default.
- W3035679306 hasConcept C2777714996 @default.
- W3035679306 hasConcept C2777914695 @default.
- W3035679306 hasConcept C509974204 @default.
- W3035679306 hasConcept C535046627 @default.
- W3035679306 hasConcept C71924100 @default.
- W3035679306 hasConceptScore W3035679306C126322002 @default.
- W3035679306 hasConceptScore W3035679306C168563851 @default.
- W3035679306 hasConceptScore W3035679306C177713679 @default.
- W3035679306 hasConceptScore W3035679306C188816634 @default.
- W3035679306 hasConceptScore W3035679306C203092338 @default.
- W3035679306 hasConceptScore W3035679306C2777714996 @default.
- W3035679306 hasConceptScore W3035679306C2777914695 @default.
- W3035679306 hasConceptScore W3035679306C509974204 @default.
- W3035679306 hasConceptScore W3035679306C535046627 @default.
- W3035679306 hasConceptScore W3035679306C71924100 @default.
- W3035679306 hasLocation W30356793061 @default.
- W3035679306 hasLocation W30356793062 @default.
- W3035679306 hasLocation W30356793063 @default.
- W3035679306 hasLocation W30356793064 @default.
- W3035679306 hasLocation W30356793065 @default.
- W3035679306 hasLocation W30356793066 @default.
- W3035679306 hasOpenAccess W3035679306 @default.
- W3035679306 hasPrimaryLocation W30356793061 @default.
- W3035679306 hasRelatedWork W1877883789 @default.
- W3035679306 hasRelatedWork W2295722933 @default.
- W3035679306 hasRelatedWork W2316236384 @default.
- W3035679306 hasRelatedWork W2384708512 @default.
- W3035679306 hasRelatedWork W2474749474 @default.
- W3035679306 hasRelatedWork W3159250744 @default.
- W3035679306 hasRelatedWork W4253808419 @default.
- W3035679306 hasRelatedWork W4256514411 @default.
- W3035679306 hasRelatedWork W4292236216 @default.
- W3035679306 hasRelatedWork W2083697902 @default.
- W3035679306 hasVolume "24" @default.
- W3035679306 isParatext "false" @default.
- W3035679306 isRetracted "false" @default.
- W3035679306 magId "3035679306" @default.
- W3035679306 workType "article" @default.