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- W3035680703 abstract "ABSTRACT Hypothesis Asbestos-driven inflammation contributes to malignant pleural mesothelioma beyond the acquisition of rate-limiting mutations. Methods Genetically modified conditional allelic mice that were previously shown to develop mesothelioma in the absence of exposure to asbestos were induced with lentiviral vector expressing Cre recombinase with and without intrapleural injection of amosite asbestos and monitored until symptoms required euthanasia. Resulting tumours were examined histologically and by immunohistochemistry for expression of lineage markers and immune cell infiltration. Results Injection of asbestos dramatically accelerated disease onset and end-stage tumour burden. Tumours initiated in the presence of asbestos showed increased macrophage infiltration. Single-agent suppression of macrophages in mice with established tumours failed to extend survival. Conclusion Asbestos-driven inflammation contributes to the severity of mesothelioma beyond the acquisition of rate-limiting mutations, however, targeted suppression of macrophages alone in established disease showed no therapeutic benefit." @default.
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- W3035680703 date "2020-06-17" @default.
- W3035680703 modified "2023-10-16" @default.
- W3035680703 title "Asbestos accelerates disease onset in a genetic model of Malignant Pleural Mesothelioma" @default.
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- W3035680703 doi "https://doi.org/10.1101/2020.06.16.154815" @default.
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