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• W3035714187 abstract "For the first time, we showed cells from medically important arthropods, such as ticks, secretes extracellular vesicles (EVs) including exosomes that mediate transmission of flavivirus RNA and proteins to the human cells. Understanding the molecular determinants and mechanism(s) of arthropod-borne flavivirus transmission via exosome biogenesis is very important. In this current study, we show that in presence of tick-borne Langat Virus (LGTV; a member of tick-borne encephalitis virus), significantly reduced the expression of arthropod IsSMase, a Sphingomyelinase D (SMase D) that catalyzes the hydrolytic cleavage of substrates like sphingomyelin lipids in both ticks (in vivo) and in tick cells (in vitro). The IsSMase reduced levels correlated with down regulation of its activity upon LGTV replication in tick cells. Our data show that LGTV-mediated suppression of IsSMase allowed accumulation of sphingomyelin (SM) lipid levels that supported membrane associated viral replication and exosome biogenesis. Inhibition of viral loads and SM lipid build up upon GW4869 inhibitor treatment reversed the IsSMase levels and restored its activity. Our results suggest an important role for this spider venomous ortholog IsSMase in regulating viral replication associated with membrane-bound SM lipids in ticks. In summary, our study not only suggests a novel role for arthropod IsSMase in tick-LGTV interactions but also provides new insights on its important function in vector defense mechanism(s) against tick-borne virus infection, and in anti-viral pathway(s)." @default.
• W3035714187 created "2020-06-19" @default.
• W3035714187 creator A5004404365 @default.
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• W3035714187 date "2020-06-12" @default.
• W3035714187 modified "2023-10-01" @default.
• W3035714187 title "Tick-Borne Flavivirus Inhibits Sphingomyelinase (IsSMase), a Venomous Spider Ortholog to Increase Sphingomyelin Lipid Levels for Its Survival in Ixodes scapularis Ticks" @default.
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• W3035714187 doi "https://doi.org/10.3389/fcimb.2020.00244" @default.
• W3035714187 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7325911" @default.
• W3035714187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32656091" @default.
• W3035714187 hasPublicationYear "2020" @default.
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