FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035732249> ?p ?o ?g. }

• W3035732249 endingPage "6844" @default.
• W3035732249 startingPage "6831" @default.
• W3035732249 abstract "The N 2 ‐position of deoxyguanosine (dG) in DNA is susceptible to modification by various damaging agents. These modifications (lesions or adducts) can stall the DNA replication by replicative polymerases, and if the common DNA repair pathways do not remove them, it can result in genomic instability. This generally leads to the death or oncogenic transformation of the cell. An important mechanism to deal with this problem is Translesion synthesis (TLS), a bypass mechanism, which involves the tolerance of DNA damage by low‐fidelity DNA polymerases (TLS polymerases). To understand the accuracy of TLS polymerases, a chemical biology approach is required. In this review, we discuss the reliable methods to synthesize specific N 2 ‐dG DNA adducts and how they are tolerated by bacterial TLS polymerase Pol IV and its mammalian orthologue hpol κ. Molecular insights on the accurate bypass of these adducts emerge from the primer extension assays, X‐ray crystallographic, and molecular modeling studies are reviewed here." @default.
• W3035732249 created "2020-06-19" @default.
• W3035732249 creator A5035166900 @default.
• W3035732249 creator A5054425260 @default.
• W3035732249 date "2020-07-13" @default.
• W3035732249 modified "2023-09-26" @default.
• W3035732249 title "Site‐Specific <i>N</i> ² ‐dG DNA Adducts: Formation, Synthesis, and TLS Polymerase‐Mediated Bypass" @default.
• W3035732249 cites W1492628327 @default.
• W3035732249 cites W1505766890 @default.
• W3035732249 cites W1527448405 @default.
• W3035732249 cites W1557945478 @default.
• W3035732249 cites W1619007532 @default.
• W3035732249 cites W1815380513 @default.
• W3035732249 cites W183795705 @default.
• W3035732249 cites W1849317485 @default.
• W3035732249 cites W1963712961 @default.
• W3035732249 cites W1964060372 @default.
• W3035732249 cites W1965795556 @default.
• W3035732249 cites W1968679294 @default.
• W3035732249 cites W1970139332 @default.
• W3035732249 cites W1970925815 @default.
• W3035732249 cites W1972116779 @default.
• W3035732249 cites W1973425860 @default.
• W3035732249 cites W1975866199 @default.
• W3035732249 cites W1975989399 @default.
• W3035732249 cites W1978323273 @default.
• W3035732249 cites W1978401222 @default.
• W3035732249 cites W1979685797 @default.
• W3035732249 cites W1980745500 @default.
• W3035732249 cites W1980783087 @default.
• W3035732249 cites W1982367621 @default.
• W3035732249 cites W1982369817 @default.
• W3035732249 cites W1985895020 @default.
• W3035732249 cites W1986726089 @default.
• W3035732249 cites W1987958662 @default.
• W3035732249 cites W1990689560 @default.
• W3035732249 cites W1990884838 @default.
• W3035732249 cites W1992107634 @default.
• W3035732249 cites W1994166791 @default.
• W3035732249 cites W1994888074 @default.
• W3035732249 cites W1999235659 @default.
• W3035732249 cites W2000958467 @default.
• W3035732249 cites W2001152383 @default.
• W3035732249 cites W2001456002 @default.
• W3035732249 cites W2002085843 @default.
• W3035732249 cites W2003913044 @default.
• W3035732249 cites W2004023033 @default.
• W3035732249 cites W2004784361 @default.
• W3035732249 cites W2005129633 @default.
• W3035732249 cites W2006119433 @default.
• W3035732249 cites W2006908561 @default.
• W3035732249 cites W2008247190 @default.
• W3035732249 cites W2011700719 @default.
• W3035732249 cites W2015294018 @default.
• W3035732249 cites W2015471659 @default.
• W3035732249 cites W2015572762 @default.
• W3035732249 cites W2015867962 @default.
• W3035732249 cites W2016455125 @default.
• W3035732249 cites W2018152583 @default.
• W3035732249 cites W2018179063 @default.
• W3035732249 cites W2018377468 @default.
• W3035732249 cites W2019775046 @default.
• W3035732249 cites W2022684980 @default.
• W3035732249 cites W2028207474 @default.
• W3035732249 cites W2028293189 @default.
• W3035732249 cites W2030418300 @default.
• W3035732249 cites W2035521675 @default.
• W3035732249 cites W2035538685 @default.
• W3035732249 cites W2040156189 @default.
• W3035732249 cites W2041434291 @default.
• W3035732249 cites W2041755595 @default.
• W3035732249 cites W2044149136 @default.
• W3035732249 cites W2046174296 @default.
• W3035732249 cites W2047360025 @default.
• W3035732249 cites W2047685397 @default.
• W3035732249 cites W2048043985 @default.
• W3035732249 cites W2049782053 @default.
• W3035732249 cites W2050236166 @default.
• W3035732249 cites W2051375737 @default.
• W3035732249 cites W2060008831 @default.
• W3035732249 cites W2060716513 @default.
• W3035732249 cites W2062281408 @default.
• W3035732249 cites W2062909384 @default.
• W3035732249 cites W2063183973 @default.
• W3035732249 cites W2068408843 @default.
• W3035732249 cites W2069003576 @default.
• W3035732249 cites W2070219690 @default.
• W3035732249 cites W2070281927 @default.
• W3035732249 cites W2070288144 @default.
• W3035732249 cites W2073557123 @default.
• W3035732249 cites W2073909798 @default.
• W3035732249 cites W2075002201 @default.
• W3035732249 cites W2075151234 @default.
• W3035732249 cites W2077066506 @default.
• W3035732249 cites W2083328999 @default.
• W3035732249 cites W2084788778 @default.
• W3035732249 cites W2085148665 @default.
• W3035732249 cites W2087156856 @default.

• next