FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035754486> ?p ?o ?g. }

• W3035754486 endingPage "119495" @default.
• W3035754486 startingPage "119495" @default.
• W3035754486 abstract "Drug particle size distribution (PSD) and dispersion viscosity are two critical quality attributes that govern the performance of topical ophthalmic suspensions, such as suspension physical stability, ocular retention, and drug release characteristics.. An in-depth knowledge of the effects of formulation and manufacturing process on these critical quality attributes may facilitate the product and process development, quality control, as well as support regulatory policy and approval. The current study has investigated the effect of formulation and process parameters on the quality attributes of brinzolamide ophthalmic suspensions. In the first step, three milling techniques (probe sonication, microfluidization, and media milling with a planetary centrifugal mixer) were evaluated for manufacturing of brinzolamide suspension. Out of the three techniques, the planetary centrifugal media milling yielded the narrowest PSD and thus was considered the most viable lab-scale technique for this purpose. In the next step, various process parameters of media milling were evaluated using a central-composite experimental design. The independent variables included bead size, agitating intensity, and process time while the PSD of drug particles (D50) was the response variable. The effect of shear rate and shear time of the homogenization process and the concentration of carbomer on the rheological properties of the suspension were studied using a Box-Behnken design. Additionally, effects of sodium chloride and mannitol concentration on the rheological properties of the suspension was also investigated. Sodium chloride was found to exert a pronounced effect on rheology of the suspension. Despite variations in the carbomer concentration, a suspension of comparable rheology could be prepared by controlling the process parameters namely the shear rate and process time." @default.
• W3035754486 created "2020-06-19" @default.
• W3035754486 creator A5005507931 @default.
• W3035754486 creator A5015421375 @default.
• W3035754486 creator A5017211373 @default.
• W3035754486 creator A5020755160 @default.
• W3035754486 creator A5022672286 @default.
• W3035754486 creator A5029588332 @default.
• W3035754486 creator A5074473841 @default.
• W3035754486 creator A5091143751 @default.
• W3035754486 date "2020-08-01" @default.
• W3035754486 modified "2023-10-12" @default.
• W3035754486 title "Factors affecting the particle size distribution and rheology of brinzolamide ophthalmic suspensions" @default.
• W3035754486 cites W1969644888 @default.
• W3035754486 cites W1983162648 @default.
• W3035754486 cites W1991551409 @default.
• W3035754486 cites W1993536841 @default.
• W3035754486 cites W2040091954 @default.
• W3035754486 cites W2041723821 @default.
• W3035754486 cites W2078340487 @default.
• W3035754486 cites W2087237823 @default.
• W3035754486 cites W2121120031 @default.
• W3035754486 cites W2170302227 @default.
• W3035754486 cites W2509178858 @default.
• W3035754486 cites W2548863366 @default.
• W3035754486 cites W2565842908 @default.
• W3035754486 cites W2607436738 @default.
• W3035754486 cites W2789539231 @default.
• W3035754486 cites W2799598689 @default.
• W3035754486 cites W2809054034 @default.
• W3035754486 cites W993968088 @default.
• W3035754486 doi "https://doi.org/10.1016/j.ijpharm.2020.119495" @default.
• W3035754486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32553495" @default.
• W3035754486 hasPublicationYear "2020" @default.
• W3035754486 type Work @default.
• W3035754486 sameAs 3035754486 @default.
• W3035754486 citedByCount "9" @default.
• W3035754486 countsByYear W30357544862020 @default.
• W3035754486 countsByYear W30357544862021 @default.
• W3035754486 countsByYear W30357544862022 @default.
• W3035754486 countsByYear W30357544862023 @default.
• W3035754486 crossrefType "journal-article" @default.
• W3035754486 hasAuthorship W3035754486A5005507931 @default.
• W3035754486 hasAuthorship W3035754486A5015421375 @default.
• W3035754486 hasAuthorship W3035754486A5017211373 @default.
• W3035754486 hasAuthorship W3035754486A5020755160 @default.
• W3035754486 hasAuthorship W3035754486A5022672286 @default.
• W3035754486 hasAuthorship W3035754486A5029588332 @default.
• W3035754486 hasAuthorship W3035754486A5074473841 @default.
• W3035754486 hasAuthorship W3035754486A5091143751 @default.
• W3035754486 hasBestOaLocation W30357544861 @default.
• W3035754486 hasConcept C105341887 @default.
• W3035754486 hasConcept C127172972 @default.
• W3035754486 hasConcept C127413603 @default.
• W3035754486 hasConcept C159985019 @default.
• W3035754486 hasConcept C165682214 @default.
• W3035754486 hasConcept C185592680 @default.
• W3035754486 hasConcept C187530423 @default.
• W3035754486 hasConcept C192562407 @default.
• W3035754486 hasConcept C200990466 @default.
• W3035754486 hasConcept C202444582 @default.
• W3035754486 hasConcept C204320433 @default.
• W3035754486 hasConcept C2780449318 @default.
• W3035754486 hasConcept C33923547 @default.
• W3035754486 hasConcept C42360764 @default.
• W3035754486 hasConcept C43617362 @default.
• W3035754486 hasConcept C5961521 @default.
• W3035754486 hasConcept C60448018 @default.
• W3035754486 hasConceptScore W3035754486C105341887 @default.
• W3035754486 hasConceptScore W3035754486C127172972 @default.
• W3035754486 hasConceptScore W3035754486C127413603 @default.
• W3035754486 hasConceptScore W3035754486C159985019 @default.
• W3035754486 hasConceptScore W3035754486C165682214 @default.
• W3035754486 hasConceptScore W3035754486C185592680 @default.
• W3035754486 hasConceptScore W3035754486C187530423 @default.
• W3035754486 hasConceptScore W3035754486C192562407 @default.
• W3035754486 hasConceptScore W3035754486C200990466 @default.
• W3035754486 hasConceptScore W3035754486C202444582 @default.
• W3035754486 hasConceptScore W3035754486C204320433 @default.
• W3035754486 hasConceptScore W3035754486C2780449318 @default.
• W3035754486 hasConceptScore W3035754486C33923547 @default.
• W3035754486 hasConceptScore W3035754486C42360764 @default.
• W3035754486 hasConceptScore W3035754486C43617362 @default.
• W3035754486 hasConceptScore W3035754486C5961521 @default.
• W3035754486 hasConceptScore W3035754486C60448018 @default.
• W3035754486 hasFunder F4320306084 @default.
• W3035754486 hasFunder F4320332163 @default.
• W3035754486 hasFunder F4320332382 @default.
• W3035754486 hasLocation W30357544861 @default.
• W3035754486 hasOpenAccess W3035754486 @default.
• W3035754486 hasPrimaryLocation W30357544861 @default.
• W3035754486 hasRelatedWork W1158984321 @default.
• W3035754486 hasRelatedWork W1839229727 @default.
• W3035754486 hasRelatedWork W2015340411 @default.
• W3035754486 hasRelatedWork W2036705824 @default.
• W3035754486 hasRelatedWork W2073750282 @default.
• W3035754486 hasRelatedWork W2235541028 @default.
• W3035754486 hasRelatedWork W2511165168 @default.

• next