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- W3035772697 abstract "It is a generally held assumption that the intranuclear order of eukaryotic DNA is essential to its ordered function and replication. The means by which this order is imposed is not altogether understood, but it has been postulated that it involves association with chromatin proteins and various sites of chromatin attachment to the nuclear membrane. The attachment of chromatin to the nuclear membrane has been observed in a number of preparations and seems ordinarily to be in close proximity to the nuclear annuli. The nature of the attachment sites and the forces involved in holding the chromatin to them is not known. In studies attempting to characterize replication regions of nuclear DNA, we have made the observation that this DNA exists in a highly ordered fashion and that the order appears to be imposed upon it by its association with some structure. This communication reports for the first time the observation of a high degree of order in eukaryotic DNA." @default.
- W3035772697 created "2020-06-25" @default.
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- W3035772697 date "1974-08-15" @default.
- W3035772697 modified "2023-09-25" @default.
- W3035772697 title "DNA Isolated from Hela Cell is Highly Ordered" @default.
- W3035772697 cites W1976668834 @default.
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- W3035772697 doi "https://doi.org/10.1017/s0424820100051360" @default.
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