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• W3035776102 abstract "ABSTRACT Rationale In addition to the overwhelming lung inflammation that prevails in COVID-19, hypercoagulation and thrombosis contribute to the lethality of subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Platelets are chiefly implicated in thrombosis. Moreover, they can interact with viruses and are an important source of inflammatory mediators. While a lower platelet count is associated with severity and mortality, little is known about platelet function during COVID-19. Objective To evaluate the contribution of platelets to inflammation and thrombosis in COVID-19 patients. Methods and Results We document the presence of SARS-CoV-2 RNA in platelets of COVID-19 patients. Exhaustive assessment of cytokines in plasma and in platelets revealed the modulation of platelet-associated cytokine levels in COVID-19, pointing to a direct contribution of platelets to the plasmatic cytokine load. Moreover, we demonstrate that platelets release their alpha- and dense-granule contents and phosphatidylserine-exposing extracellular vesicles. Functionally, platelets were hyperactivated in COVID-19 subjects, with aggregation occurring at suboptimal thrombin concentrations. Furthermore, platelets adhered more efficiently onto collagen-coated surfaces under flow conditions. Conclusions These data suggest that platelets could participate in the dissemination of SARS-CoV-2 and in the overwhelming thrombo-inflammation observed in COVID-19. Thus, blockade of platelet activation pathways may improve outcomes in this disease. KEY POINTS Platelets are a source of inflammatory cytokines and degranulate in COVID-19 Platelets contain SARS-CoV-2 RNA molecules and are prone to activation in COVID-19 Subject terms Infectious diseases/Emerging infectious diseases, SARS-CoV-2, COVID-19, Hematology, Platelets" @default.
• W3035776102 created "2020-06-25" @default.
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• W3035776102 date "2020-06-23" @default.
• W3035776102 modified "2023-09-24" @default.
• W3035776102 title "Platelets can contain SARS-CoV-2 RNA and are hyperactivated in COVID-19" @default.
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• W3035776102 cites W1980652099 @default.
• W3035776102 cites W1983927535 @default.
• W3035776102 cites W1990341278 @default.
• W3035776102 cites W1994768909 @default.
• W3035776102 cites W1998599956 @default.
• W3035776102 cites W2016685455 @default.
• W3035776102 cites W2025672718 @default.
• W3035776102 cites W2028370526 @default.
• W3035776102 cites W2036706643 @default.
• W3035776102 cites W2041158684 @default.
• W3035776102 cites W2054540030 @default.
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• W3035776102 cites W2078817520 @default.
• W3035776102 cites W2083642109 @default.
• W3035776102 cites W2087065938 @default.
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• W3035776102 cites W2414595006 @default.
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• W3035776102 cites W2476500174 @default.
• W3035776102 cites W2577760293 @default.
• W3035776102 cites W2600669583 @default.
• W3035776102 cites W2620594759 @default.
• W3035776102 cites W2792067873 @default.
• W3035776102 cites W2868386614 @default.
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• W3035776102 cites W3016404849 @default.
• W3035776102 cites W3016406354 @default.
• W3035776102 cites W3017014626 @default.
• W3035776102 cites W3017150431 @default.
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• W3035776102 cites W3023873927 @default.
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• W3035776102 doi "https://doi.org/10.1101/2020.06.23.20137596" @default.
• W3035776102 hasPublicationYear "2020" @default.
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