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• W3035780070 endingPage "108059" @default.
• W3035780070 startingPage "108059" @default.
• W3035780070 abstract "Methamphetamine (METH) use is a public health crisis that disproportionately affects men who have sex with men (MSM). There are currently no FDA-approved pharmacological interventions to treat methamphetamine use disorder (MUD). MUD is associated with social impairments and extremely high treatment attrition rates. Administration of oxytocin, a neuropeptide involved in social attachment, may be a novel approach to addressing these issues. Moreover, oxytocin administration has shown promise for reducing METH-related addictive behavior in animal models, but has not yet been investigated in clinical trials for MUD. Last, oxytocin is known to modulate stress responsivity via regulation of the autonomic nervous system, which is dysregulated in METH users. We hypothesize that oxytocin, in combination with group psychotherapy, will increase treatment engagement, reduce addiction behavior, and mitigate stress hyperreactivity.This is a randomized, double blind trial of oxytocin 40-IU (n = 24) or placebo (n = 24) administered intranasally prior to each of six weekly motivational interviewing group therapy (MIGT) sessions for MUD in MSM.(a) session attendance.(b) group cohesion, (c) anxiety, (d) METH craving, (e) METH use, and (f) in-session cardiac physiology.Participants receiving oxytocin had significantly higher group therapy attendance than those receiving placebo, OR 3.26, 95% CI [1.27-8.41], p = .014. There was a small effect of oxytocin on group cohension, but not anxiety or craving. METH use did not change over the six-week MIGT course in either treatment arm. Participants receiving oxytocin had lower average heart rates during MIGT sessions and higher heart rate variability. There were positive main effects of MIGT over Time regardless of study drug.This evidence, and the lack of any serious adverse events, suggests that oxytocin may safely increase treatment attendance. One possible mechanism by which it may do so is its modulation of the autonomic nervous system. Further investigation is warranted." @default.
• W3035780070 created "2020-06-25" @default.
• W3035780070 creator A5008587847 @default.
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• W3035780070 date "2020-09-01" @default.
• W3035780070 modified "2023-10-09" @default.
• W3035780070 title "Oxytocin-enhanced group therapy for methamphetamine use disorder: Randomized controlled trial" @default.
• W3035780070 cites W1067107096 @default.
• W3035780070 cites W1570177053 @default.
• W3035780070 cites W1595671608 @default.
• W3035780070 cites W1627848973 @default.
• W3035780070 cites W1744359224 @default.
• W3035780070 cites W1750764127 @default.
• W3035780070 cites W1846667482 @default.
• W3035780070 cites W1888419634 @default.
• W3035780070 cites W1898877040 @default.
• W3035780070 cites W1968830408 @default.
• W3035780070 cites W1969137999 @default.
• W3035780070 cites W1976108278 @default.
• W3035780070 cites W1981459575 @default.
• W3035780070 cites W1985605151 @default.
• W3035780070 cites W1991048992 @default.
• W3035780070 cites W1991163868 @default.
• W3035780070 cites W1995077547 @default.
• W3035780070 cites W1995414430 @default.
• W3035780070 cites W2010189130 @default.
• W3035780070 cites W2017323063 @default.
• W3035780070 cites W2020743147 @default.
• W3035780070 cites W2028244020 @default.
• W3035780070 cites W2032553935 @default.
• W3035780070 cites W2039804055 @default.
• W3035780070 cites W2050876878 @default.
• W3035780070 cites W2051405502 @default.
• W3035780070 cites W2053772322 @default.
• W3035780070 cites W2054657132 @default.
• W3035780070 cites W2055559081 @default.
• W3035780070 cites W2057104097 @default.
• W3035780070 cites W2057967199 @default.
• W3035780070 cites W2061519370 @default.
• W3035780070 cites W2063085086 @default.
• W3035780070 cites W2067577447 @default.
• W3035780070 cites W2087359530 @default.
• W3035780070 cites W2090086966 @default.
• W3035780070 cites W2091124963 @default.
• W3035780070 cites W2093186581 @default.
• W3035780070 cites W2093318649 @default.
• W3035780070 cites W2093553894 @default.
• W3035780070 cites W2093847097 @default.
• W3035780070 cites W2100442727 @default.
• W3035780070 cites W2106883989 @default.
• W3035780070 cites W2108489413 @default.
• W3035780070 cites W2111804329 @default.
• W3035780070 cites W2112073367 @default.
• W3035780070 cites W2115705437 @default.
• W3035780070 cites W2116839388 @default.
• W3035780070 cites W2128657693 @default.
• W3035780070 cites W2128948700 @default.
• W3035780070 cites W2130703925 @default.
• W3035780070 cites W2132653311 @default.
• W3035780070 cites W2135120423 @default.
• W3035780070 cites W2137265736 @default.
• W3035780070 cites W2142960568 @default.
• W3035780070 cites W2144120285 @default.
• W3035780070 cites W2144385521 @default.
• W3035780070 cites W2147066769 @default.
• W3035780070 cites W2147412087 @default.
• W3035780070 cites W2150906686 @default.
• W3035780070 cites W2155243985 @default.
• W3035780070 cites W2155609494 @default.
• W3035780070 cites W2158328250 @default.
• W3035780070 cites W2167829495 @default.
• W3035780070 cites W2167858076 @default.
• W3035780070 cites W2200148958 @default.
• W3035780070 cites W2289138162 @default.
• W3035780070 cites W2398339362 @default.
• W3035780070 cites W2415392279 @default.
• W3035780070 cites W2510160646 @default.
• W3035780070 cites W2515748080 @default.
• W3035780070 cites W2555084569 @default.
• W3035780070 cites W2557831994 @default.
• W3035780070 cites W2579674377 @default.
• W3035780070 cites W2588660371 @default.
• W3035780070 cites W2601916337 @default.
• W3035780070 cites W2609065061 @default.
• W3035780070 cites W2747645283 @default.
• W3035780070 cites W2752326235 @default.
• W3035780070 cites W2759190050 @default.
• W3035780070 cites W2764232586 @default.
• W3035780070 cites W2771760013 @default.
• W3035780070 cites W2774486220 @default.

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