FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035787046> ?p ?o ?g. }

• W3035787046 endingPage "4339" @default.
• W3035787046 startingPage "4339" @default.
• W3035787046 abstract "Introduction: The global burden of chronic airway diseases represents an important public health concern. The role of oxidative stress and inflammation in the pathogenesis of these diseases is well known. The aim of this study is to evaluate the behavior of both inflammatory and oxidative stress biomarkers in patients with chronic bronchitis, current asthma and past asthma in the frame of a population-based study. Methods: For this purpose, data collected from the Gene Environment Interactions in Respiratory Diseases (GEIRD) Study, an Italian multicentre, multicase-control study, was evaluated. Cases and controls were identified through a two-stage screening process of individuals aged 20-65 years from the general population. Out of 16,569 subjects selected from the general population in the first stage of the survey, 2259 participated in the clinical evaluation. Oxidative stress biomarkers such as 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), 8-isoprostane and glutathione and inflammatory biomarkers such as Fractional Exhaled Nitric Oxide (FENO) and white blood cells were evaluated in 1878 subjects. Results: Current asthmatics presented higher levels of FENO (23.05 ppm), leucocytes (6770 n/µL), basophils (30.75 n/µL) and eosinophils (177.80 n/µL), while subjects with chronic bronchitis showed higher levels of GSH (0.29 mg/mL) and lymphocytes (2101.6 n/µL). The multivariable multinomial logistic regression confirmed high levels of leucocytes (RRR = 1.33), basophils (RRR = 1.48), eosinophils (RRR = 2.39), lymphocytes (RRR = 1.26) and FENO (RRR = 1.42) in subjects with current asthma. Subjects with past asthma had a statistically significant higher level of eosinophils (RRR = 1.78) with respect to controls. Subjects with chronic bronchitis were characterized by increased levels of eosinophils (RRR = 2.15), lymphocytes (RRR = 1.58), GSH (RRR = 2.23) and 8-isoprostane (RRR = 1.23). Conclusion: In our study, current asthmatics show a greater expression of the inflammatory profile compared to subjects who have had asthma in the past and chronic bronchitis. On the other hand, chronic bronchitis subjects showed a higher rate of expression of oxidative stress biomarkers compared to asthmatic subjects. In particular, inflammatory markers such as circulating inflammatory cells and FENO seem to be more specific for current asthma, while oxidative stress biomarkers such as glutathione and 8-isoprostane appear to be more specific and applicable to patients with chronic bronchitis." @default.
• W3035787046 created "2020-06-25" @default.
• W3035787046 creator A5009192139 @default.
• W3035787046 creator A5011868322 @default.
• W3035787046 creator A5023892401 @default.
• W3035787046 creator A5026864121 @default.
• W3035787046 creator A5031705386 @default.
• W3035787046 creator A5036532466 @default.
• W3035787046 creator A5037099508 @default.
• W3035787046 creator A5044654120 @default.
• W3035787046 creator A5054864283 @default.
• W3035787046 creator A5055493176 @default.
• W3035787046 creator A5056547245 @default.
• W3035787046 creator A5061335816 @default.
• W3035787046 creator A5062161519 @default.
• W3035787046 creator A5076034418 @default.
• W3035787046 creator A5079590668 @default.
• W3035787046 creator A5082412508 @default.
• W3035787046 date "2020-06-18" @default.
• W3035787046 modified "2023-10-18" @default.
• W3035787046 title "Biomarkers of Oxidative Stress and Inflammation in Chronic Airway Diseases" @default.
• W3035787046 cites W1553126713 @default.
• W3035787046 cites W1967468829 @default.
• W3035787046 cites W1976780217 @default.
• W3035787046 cites W1978453301 @default.
• W3035787046 cites W1980164182 @default.
• W3035787046 cites W1991030758 @default.
• W3035787046 cites W1995137037 @default.
• W3035787046 cites W1999890347 @default.
• W3035787046 cites W2000498200 @default.
• W3035787046 cites W2004225647 @default.
• W3035787046 cites W2012616263 @default.
• W3035787046 cites W2020563115 @default.
• W3035787046 cites W2022727685 @default.
• W3035787046 cites W2023415666 @default.
• W3035787046 cites W2027767665 @default.
• W3035787046 cites W2029088672 @default.
• W3035787046 cites W2039493835 @default.
• W3035787046 cites W2058798563 @default.
• W3035787046 cites W2078561688 @default.
• W3035787046 cites W2079822311 @default.
• W3035787046 cites W2093680901 @default.
• W3035787046 cites W2105998421 @default.
• W3035787046 cites W2121739711 @default.
• W3035787046 cites W2130318195 @default.
• W3035787046 cites W2130402304 @default.
• W3035787046 cites W2141647716 @default.
• W3035787046 cites W2143920627 @default.
• W3035787046 cites W2145142891 @default.
• W3035787046 cites W2152276343 @default.
• W3035787046 cites W2153034426 @default.
• W3035787046 cites W2158863922 @default.
• W3035787046 cites W2167725249 @default.
• W3035787046 cites W2331225458 @default.
• W3035787046 cites W2401306489 @default.
• W3035787046 cites W2604596332 @default.
• W3035787046 cites W2769789030 @default.
• W3035787046 cites W2884695255 @default.
• W3035787046 cites W2887622862 @default.
• W3035787046 cites W2898582893 @default.
• W3035787046 cites W2994597783 @default.
• W3035787046 cites W3025465781 @default.
• W3035787046 cites W4247786052 @default.
• W3035787046 cites W4298774464 @default.
• W3035787046 doi "https://doi.org/10.3390/ijms21124339" @default.
• W3035787046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7353047" @default.
• W3035787046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32570774" @default.
• W3035787046 hasPublicationYear "2020" @default.
• W3035787046 type Work @default.
• W3035787046 sameAs 3035787046 @default.
• W3035787046 citedByCount "25" @default.
• W3035787046 countsByYear W30357870462021 @default.
• W3035787046 countsByYear W30357870462022 @default.
• W3035787046 countsByYear W30357870462023 @default.
• W3035787046 crossrefType "journal-article" @default.
• W3035787046 hasAuthorship W3035787046A5009192139 @default.
• W3035787046 hasAuthorship W3035787046A5011868322 @default.
• W3035787046 hasAuthorship W3035787046A5023892401 @default.
• W3035787046 hasAuthorship W3035787046A5026864121 @default.
• W3035787046 hasAuthorship W3035787046A5031705386 @default.
• W3035787046 hasAuthorship W3035787046A5036532466 @default.
• W3035787046 hasAuthorship W3035787046A5037099508 @default.
• W3035787046 hasAuthorship W3035787046A5044654120 @default.
• W3035787046 hasAuthorship W3035787046A5054864283 @default.
• W3035787046 hasAuthorship W3035787046A5055493176 @default.
• W3035787046 hasAuthorship W3035787046A5056547245 @default.
• W3035787046 hasAuthorship W3035787046A5061335816 @default.
• W3035787046 hasAuthorship W3035787046A5062161519 @default.
• W3035787046 hasAuthorship W3035787046A5076034418 @default.
• W3035787046 hasAuthorship W3035787046A5079590668 @default.
• W3035787046 hasAuthorship W3035787046A5082412508 @default.
• W3035787046 hasBestOaLocation W30357870461 @default.
• W3035787046 hasConcept C126322002 @default.
• W3035787046 hasConcept C203014093 @default.
• W3035787046 hasConcept C2776042228 @default.
• W3035787046 hasConcept C2776151105 @default.
• W3035787046 hasConcept C2780333948 @default.
• W3035787046 hasConcept C2781142857 @default.

• next