FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035804151> ?p ?o ?g. }

• W3035804151 endingPage "41" @default.
• W3035804151 startingPage "41" @default.
• W3035804151 abstract "Purpose: The tumor-initiating function of long non-coding RNA (lncRNA), zinc finger protein multitype 2 antisense RNA 1 (ZFPM2-AS1) was reported in lung cancer, yet the relevance of ZFPM2-AS1 in retinoblastoma (RB), a malignancy representing 2.5% to 4% incidence of cancers among children, has not been elucidated. Thus, we attempted to assess the effect of ZFPM2-AS1 and underlying mechanism in RB progression. Methods: First, comparing the differentially expressed lncRNAs in normal retinal tissues as well as RB tissues, the target lncRNA ZFPM2-AS1 was screened out. We then assayed the ZFPM2-AS1 expression in three RB cell lines, and carried out methylthiazol tetrazolium (MTT), transwell assays, and flow cytometric analyses to examine the role of si-ZFPM2-AS1 on cell behaviors. Following online database predication, the correlations between ZFPM2-AS1 and microR-515 (miR-515) or homeobox A1 (HOXA1) were corroborated by dual-luciferase reporter gene assays. Quantitative real-time PCR along with Western blot assays was fulfilled to ascertain the expression of relevant genes. Results: ZFPM2-AS1 was significantly overexpressed in RB tissues and cell lines, and ZFPM2-AS1 silencing curtailed the growth and metastasis of RB cells both in vitro and in vivo. Bioinformatic websites and dual-luciferase reporter gene assays disclosed that ZFPM2-AS1 might perform as a competing endogenous RNA for miR-515 and positively correlate with HOXA1 to activate the Wnt/β-catenin signaling pathway. Conclusion: Altogether, these data demonstrated that ZFPM2-AS1 interacted with HOXA1 to promote RB development via mediating miR-515, establishing a promising therapeutic biomarker for RB and prognosis." @default.
• W3035804151 created "2020-06-25" @default.
• W3035804151 creator A5023979872 @default.
• W3035804151 creator A5035951209 @default.
• W3035804151 creator A5042947574 @default.
• W3035804151 creator A5046215121 @default.
• W3035804151 creator A5069849278 @default.
• W3035804151 creator A5077058548 @default.
• W3035804151 date "2020-06-19" @default.
• W3035804151 modified "2023-09-27" @default.
• W3035804151 title "Long Noncoding RNA ZFPM2-AS1 Knockdown Restrains the Development of Retinoblastoma by Modulating the MicroRNA-515/HOXA1/Wnt/β-Catenin Axis" @default.
• W3035804151 cites W1902808961 @default.
• W3035804151 cites W1907172454 @default.
• W3035804151 cites W2001974204 @default.
• W3035804151 cites W2017327503 @default.
• W3035804151 cites W2020610342 @default.
• W3035804151 cites W2046387002 @default.
• W3035804151 cites W2074542604 @default.
• W3035804151 cites W2142877023 @default.
• W3035804151 cites W2255131494 @default.
• W3035804151 cites W2287061185 @default.
• W3035804151 cites W2735687500 @default.
• W3035804151 cites W2767807008 @default.
• W3035804151 cites W2838549027 @default.
• W3035804151 cites W2883052116 @default.
• W3035804151 cites W2892372616 @default.
• W3035804151 cites W2900799779 @default.
• W3035804151 cites W2913712917 @default.
• W3035804151 cites W2963281600 @default.
• W3035804151 cites W2980882117 @default.
• W3035804151 cites W2986503459 @default.
• W3035804151 cites W2998250399 @default.
• W3035804151 cites W4233854028 @default.
• W3035804151 cites W4243373012 @default.
• W3035804151 cites W4246827428 @default.
• W3035804151 cites W4250018597 @default.
• W3035804151 cites W4254948004 @default.
• W3035804151 doi "https://doi.org/10.1167/iovs.61.6.41" @default.
• W3035804151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7415309" @default.
• W3035804151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32561925" @default.
• W3035804151 hasPublicationYear "2020" @default.
• W3035804151 type Work @default.
• W3035804151 sameAs 3035804151 @default.
• W3035804151 citedByCount "17" @default.
• W3035804151 countsByYear W30358041512020 @default.
• W3035804151 countsByYear W30358041512021 @default.
• W3035804151 countsByYear W30358041512022 @default.
• W3035804151 countsByYear W30358041512023 @default.
• W3035804151 crossrefType "journal-article" @default.
• W3035804151 hasAuthorship W3035804151A5023979872 @default.
• W3035804151 hasAuthorship W3035804151A5035951209 @default.
• W3035804151 hasAuthorship W3035804151A5042947574 @default.
• W3035804151 hasAuthorship W3035804151A5046215121 @default.
• W3035804151 hasAuthorship W3035804151A5069849278 @default.
• W3035804151 hasAuthorship W3035804151A5077058548 @default.
• W3035804151 hasBestOaLocation W30358041511 @default.
• W3035804151 hasConcept C104317684 @default.
• W3035804151 hasConcept C119056186 @default.
• W3035804151 hasConcept C137620995 @default.
• W3035804151 hasConcept C150194340 @default.
• W3035804151 hasConcept C153911025 @default.
• W3035804151 hasConcept C173396325 @default.
• W3035804151 hasConcept C202416437 @default.
• W3035804151 hasConcept C2776577112 @default.
• W3035804151 hasConcept C502942594 @default.
• W3035804151 hasConcept C54355233 @default.
• W3035804151 hasConcept C60365752 @default.
• W3035804151 hasConcept C62203573 @default.
• W3035804151 hasConcept C67705224 @default.
• W3035804151 hasConcept C86803240 @default.
• W3035804151 hasConceptScore W3035804151C104317684 @default.
• W3035804151 hasConceptScore W3035804151C119056186 @default.
• W3035804151 hasConceptScore W3035804151C137620995 @default.
• W3035804151 hasConceptScore W3035804151C150194340 @default.
• W3035804151 hasConceptScore W3035804151C153911025 @default.
• W3035804151 hasConceptScore W3035804151C173396325 @default.
• W3035804151 hasConceptScore W3035804151C202416437 @default.
• W3035804151 hasConceptScore W3035804151C2776577112 @default.
• W3035804151 hasConceptScore W3035804151C502942594 @default.
• W3035804151 hasConceptScore W3035804151C54355233 @default.
• W3035804151 hasConceptScore W3035804151C60365752 @default.
• W3035804151 hasConceptScore W3035804151C62203573 @default.
• W3035804151 hasConceptScore W3035804151C67705224 @default.
• W3035804151 hasConceptScore W3035804151C86803240 @default.
• W3035804151 hasIssue "6" @default.
• W3035804151 hasLocation W30358041511 @default.
• W3035804151 hasLocation W30358041512 @default.
• W3035804151 hasOpenAccess W3035804151 @default.
• W3035804151 hasPrimaryLocation W30358041511 @default.
• W3035804151 hasRelatedWork W2620050290 @default.
• W3035804151 hasRelatedWork W2753482964 @default.
• W3035804151 hasRelatedWork W2887190758 @default.
• W3035804151 hasRelatedWork W2889935627 @default.
• W3035804151 hasRelatedWork W2980955790 @default.
• W3035804151 hasRelatedWork W3013986030 @default.
• W3035804151 hasRelatedWork W3016780228 @default.
• W3035804151 hasRelatedWork W3127683711 @default.
• W3035804151 hasRelatedWork W4226017683 @default.

• next