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- W3035809321 abstract "Complete renal ischemia causes a series of subcellular changes including chromatin clumping, dilation of endoplasmic reticulum and condensation of mitochondrial matrix followed by swelling of the mitochondria and unfolding of the cristae (1). Most mitochondria are condensed by 15 minutes and half are condensed and half swollen by 30 minutes with the majority of the mitochondria swollen by 60 minutes of ischemia. In this study we have looked at the ability of mitochondria isolated from ischemic rat kidneys to undergo structural energy transformations in the presence of substrate and ADP. Mitochondria were isolated from the inner cortex of rat kidney where initial damage from ischemia occurs. The tissue was diced in the cold, homogenized with a Dounce homogenizer, spun twice at 600 g, and the supernatant at 15,000 g for pelleting of mitochondria." @default.
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- W3035809321 date "1977-01-01" @default.
- W3035809321 modified "2023-09-26" @default.
- W3035809321 title "Ultrastructure of Isolated Mitochondria from the Renal Cortex after Reversible and Irreversible Ischemia in the Rat" @default.
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- W3035809321 doi "https://doi.org/10.1017/s0424820100079516" @default.
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