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- W3035810475 abstract "During Drosophila oogenesis, the localization and translational regulation of maternal transcripts relies on RNA-binding proteins (RBPs). Many of these RBPs localize several mRNAs and may have additional direct interaction partners to regulate their functions. Using immunoprecipitation from whole Drosophila ovaries coupled to mass spectrometry, we examined protein-protein associations of 6 GFP-tagged RBPs expressed at physiological levels. Analysis of the interaction network and further validation in human cells allowed us to identify 26 previously unknown associations, besides recovering several well characterized interactions. We identified interactions between RBPs and several splicing factors, providing links between nuclear and cytoplasmic events of mRNA regulation. Additionally, components of the translational and RNA decay machineries were selectively co-purified with some baits, suggesting a mechanism for how RBPs may regulate maternal transcripts. Given the evolutionary conservation of the studied RBPs, the interaction network presented here provides the foundation for future functional and structural studies of mRNA localization across metazoans." @default.
- W3035810475 created "2020-06-25" @default.
- W3035810475 creator A5002310732 @default.
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- W3035810475 creator A5062230417 @default.
- W3035810475 creator A5079814195 @default.
- W3035810475 creator A5085238149 @default.
- W3035810475 date "2020-09-01" @default.
- W3035810475 modified "2023-10-13" @default.
- W3035810475 title "An Interaction Network of RNA-Binding Proteins Involved in Drosophila Oogenesis" @default.
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