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- W3035819944 abstract "Vertigo may be induced by various factors such as vascular changes including arteriosclerosis and hypercholesterolemia in the inner ear. In orter to clarify the mechanism of vertigo, the inner ear of guinea pig in hypercholesterolemia condition was investigated by electron microscopic techniques. The guinea pigs have served as experimental materials. They were divided into two groups: one received non-administration of cholesterol and the other received the administration of cholesterol. The vestibular macula in inner ear were observed at 1, 2 and 3 months after the administration of cholesterol and also vascular function was investigated by using horseradish peroxidase as tracer. Ultrastructural changes such as the depletion of microvilli on the cell surface and increased microvesicles were detected in the cytoplasm of sensory cell after cholesterol administration. After two months, lipid droplets were demonstrated in the cytoplasm, associated with intercellular edema. The cytoplasmic projection with vacuolization was demonstrated in the surface of sensory cells in the vestibular macula after three months of cholesterol administration." @default.
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- W3035819944 date "1993-08-01" @default.
- W3035819944 modified "2023-10-18" @default.
- W3035819944 title "Electron Microscopic study of inner ear of guinea pig with special reference to morphological changes in vestibular macula in hypercholesterolemia" @default.
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- W3035819944 doi "https://doi.org/10.1017/s0424820100147983" @default.
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