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• W3035829821 abstract "To study the agreement between proton microdosimetric distributions measured with a silicon-based cylindrical microdosimeter and a previously published analytical microdosimetric model based on Geant4-DNA in-water Monte Carlo simulations for low energy proton beams.Distributions for lineal energy (y) are measured for four proton monoenergetic beams with nominal energies from 2.0 MeV to 4.5 MeV, with a tissue equivalent proportional counter (TEPC) and a silicon-based microdosimeter. The actual energy for protons traversing the silicon-based microdosimeter is simulated with SRIM. Monoenergetic beams with these energies are simulated with Geant4-DNA code by simulating a water cylinder site of dimensions equal to those of the microdosimeter. The microdosimeter response is calibrated by using the distribution peaks obtained from the TEPC. Analytical calculations for y¯F and y¯D using our methodology based on spherical sites are also performed choosing the equivalent sphere to be checked against experimental results.Distributions for y at silicon are converted into tissue equivalent and compared to the Geant4-DNA simulated, yielding maximum deviations of 1.03% for y¯F and 1.17% for y¯D . Our analytical method generates maximum deviations of 1.29% and 3.33%, respectively, with respect to experimental results.Simulations in Geant4-DNA with ideal cylindrical sites in liquid water produce similar results to the measurements in an actual silicon-based cylindrical microdosimeter properly calibrated. The found agreement suggests the possibility to experimentally verify the calculated clinical y¯D with our analytical method." @default.
• W3035829821 created "2020-06-25" @default.
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• W3035829821 date "2020-11-01" @default.
• W3035829821 modified "2023-10-16" @default.
• W3035829821 title "Experimental validation of an analytical microdosimetric model based on Geant4-DNA simulations by using a silicon-based microdosimeter" @default.
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• W3035829821 doi "https://doi.org/10.1016/j.radphyschem.2020.109060" @default.
• W3035829821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7583143" @default.
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