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• W3035830082 abstract "Abstract Metabolism across all known living systems combines two key features. First, all of the molecules that are required are either available in the environment or can be built up from available resources via other reactions within the system. Second, the reactions proceed in a fast and synchronised fashion via catalysts that are also produced within the system. Building on early work by Stuart Kauffman, a precise mathematical model for describing such self-sustaining autocatalytic systems (RAF theory) has been developed to explore the origins and organisation of living systems within a general formal framework. In this paper, we develop this theory further by establishing new relationships between classes of RAFs and related classes of networks, and developing new algorithms to investigate and visualise RAF structures in detail. We illustrate our results by showing how it reveals further details into the structure of archaeal and bacterial metabolism near the origin of life, and provide techniques to study and visualise the core aspects of primitive biochemistry." @default.
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• W3035830082 date "2020-06-18" @default.
• W3035830082 modified "2023-09-23" @default.
• W3035830082 title "The structure of autocatalytic networks, with application to early biochemistry" @default.
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• W3035830082 doi "https://doi.org/10.1101/2020.06.18.158139" @default.
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