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- W3035830851 abstract "Epithelial–mesenchymal transition (EMT) is an important process of cell remodeling characterized by the gradual loss of the epithelial phenotype and progressive gain of a mesenchymal phenotype. EMT is not an all-or-nothing process, but instead a transition of epithelial to mesenchymal cells with intermediate cell states. Recently, EMT was described in endometriosis, and many EMT-specific pathways like Twist, Snail, Slug, Zinc finger E-box-binding homeobox 1/2 (ZEB1/2), E/N-cadherin, keratins, and claudins are involved. However, as pointed out in this review, a comparison of the eutopic endometrium of women with and without endometriosis yielded only subtle changes of these EMT markers. Furthermore, only very few alterations in cell–cell contacts could be found but without changes in the epithelial phenotype. This suggests only a partial EMT which is not a prerequisite for the detachment of endometrial cells and, thus, not critical for the first step(s) in the pathogenesis of endometriosis. In contrast, the majority of changes in the EMT-related marker expression were found in the ectopic endometrium, especially in the three endometriotic entities, ovarian, peritoneal, and deep infiltrating endometriosis (DIE), compared with the eutopic endometrium. In this review, we examine the most important EMT pathways described in endometriosis and propose that partial EMT might result from the interaction of endometrial implants with their surrounding microenvironment." @default.
- W3035830851 created "2020-06-25" @default.
- W3035830851 creator A5009505785 @default.
- W3035830851 creator A5026660760 @default.
- W3035830851 creator A5036106701 @default.
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- W3035830851 creator A5083996371 @default.
- W3035830851 creator A5085171232 @default.
- W3035830851 creator A5090281574 @default.
- W3035830851 date "2020-06-18" @default.
- W3035830851 modified "2023-10-09" @default.
- W3035830851 title "Epithelial–Mesenchymal Transition in Endometriosis—When Does It Happen?" @default.
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