FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035846598> ?p ?o ?g. }

• W3035846598 endingPage "382" @default.
• W3035846598 startingPage "367" @default.
• W3035846598 abstract "Pericytes (PCs) are a type of perivascular cells that surround endothelial cells of small blood vessels. In the brain, PCs show heterogeneity depending on their position within the vasculature. As a result, PC interactions with surrounding endothelial cells, astrocytes, and neuron cells play a key role in a wide array of neurovascular functions such as regulating blood–brain barrier (BBB) permeability, cerebral blood flow, and helping to facilitate the clearance of toxic cellular molecules. Therefore, a reliable method of engineering brain-specific PCs from human induced pluripotent stem cells (hiPSCs) is critical in neurodegenerative disease modeling. This review summarizes brain-specific PC differentiation of hiPSCs through mesoderm and neural crest induction. Key signaling pathways (platelet-derived growth factor-B [PDGF-B], transforming growth factor [TGF]-β, and Notch signaling) regulating PC function, PC interactions with adjacent cells, and PC differentiation from hiPSCs are also discussed. Specifically, PDGF-BB-platelet-derived growth factor receptor β signaling promotes PC cell survival, TGF-β signal transduction facilitates PC attachment to endothelial cells, and Notch signaling is critical in vascular development and arterial-venous specification. Furthermore, current challenges facing the use of hiPSC-derived PCs are discussed, and their ongoing uses in neurodegenerative disease modeling are identified. Further investigations into PCs and surrounding cell interactions are needed to characterize the roles of brain PCs in various neurodegenerative disorders. This article summarizes the work related to brain-specific pericytes (PCs) derived from human pluripotent stem cells (hPSCs). In particular, key signaling pathways regulating PC function, PC interactions with adjacent cells, and PC differentiation from hPSCs were discussed. Furthermore, current challenges facing the use of hPSC-derived PCs were identified, and their ongoing uses in neurodegenerative disease modeling were discussed. The review highlights the important role of cell–cell interactions in blood–brain barrier (BBB) models and neurodegeneration. The summarized findings are significant for establishing pluripotent stem cell-based BBB models toward the applications in drug screening and disease modeling." @default.
• W3035846598 created "2020-06-25" @default.
• W3035846598 creator A5023683242 @default.
• W3035846598 creator A5041764614 @default.
• W3035846598 creator A5052692599 @default.
• W3035846598 creator A5081579642 @default.
• W3035846598 creator A5081704833 @default.
• W3035846598 date "2020-08-01" @default.
• W3035846598 modified "2023-10-18" @default.
• W3035846598 title "Engineering Brain-Specific Pericytes from Human Pluripotent Stem Cells" @default.
• W3035846598 cites W1630483749 @default.
• W3035846598 cites W1768846296 @default.
• W3035846598 cites W1815758482 @default.
• W3035846598 cites W1893055997 @default.
• W3035846598 cites W1966621970 @default.
• W3035846598 cites W1972157709 @default.
• W3035846598 cites W1973626590 @default.
• W3035846598 cites W1983920067 @default.
• W3035846598 cites W1988213225 @default.
• W3035846598 cites W1996631625 @default.
• W3035846598 cites W1998099768 @default.
• W3035846598 cites W2001726213 @default.
• W3035846598 cites W2003708432 @default.
• W3035846598 cites W2003986538 @default.
• W3035846598 cites W2006035554 @default.
• W3035846598 cites W2019780808 @default.
• W3035846598 cites W2027597986 @default.
• W3035846598 cites W2042883482 @default.
• W3035846598 cites W2047153310 @default.
• W3035846598 cites W2048488159 @default.
• W3035846598 cites W2050497029 @default.
• W3035846598 cites W2051386121 @default.
• W3035846598 cites W2055467683 @default.
• W3035846598 cites W2056856515 @default.
• W3035846598 cites W2059550462 @default.
• W3035846598 cites W2069929255 @default.
• W3035846598 cites W2073290778 @default.
• W3035846598 cites W2076491580 @default.
• W3035846598 cites W2086914356 @default.
• W3035846598 cites W2096145966 @default.
• W3035846598 cites W2096515612 @default.
• W3035846598 cites W2104281661 @default.
• W3035846598 cites W2104869587 @default.
• W3035846598 cites W2107325549 @default.
• W3035846598 cites W2109290881 @default.
• W3035846598 cites W2120294814 @default.
• W3035846598 cites W2121973883 @default.
• W3035846598 cites W2125281412 @default.
• W3035846598 cites W2125411036 @default.
• W3035846598 cites W2129553803 @default.
• W3035846598 cites W2132330583 @default.
• W3035846598 cites W2139123746 @default.
• W3035846598 cites W2142177110 @default.
• W3035846598 cites W2152250062 @default.
• W3035846598 cites W2152895485 @default.
• W3035846598 cites W2280695772 @default.
• W3035846598 cites W2289500363 @default.
• W3035846598 cites W2291751883 @default.
• W3035846598 cites W2329803151 @default.
• W3035846598 cites W2336973322 @default.
• W3035846598 cites W2336992139 @default.
• W3035846598 cites W2343599230 @default.
• W3035846598 cites W2344851265 @default.
• W3035846598 cites W2398824758 @default.
• W3035846598 cites W2399776559 @default.
• W3035846598 cites W2461708130 @default.
• W3035846598 cites W2522759545 @default.
• W3035846598 cites W2531568380 @default.
• W3035846598 cites W2531888678 @default.
• W3035846598 cites W2536398251 @default.
• W3035846598 cites W2547945396 @default.
• W3035846598 cites W2562254730 @default.
• W3035846598 cites W2573812177 @default.
• W3035846598 cites W2581423712 @default.
• W3035846598 cites W2582407848 @default.
• W3035846598 cites W2601589334 @default.
• W3035846598 cites W2605691032 @default.
• W3035846598 cites W2605762341 @default.
• W3035846598 cites W2606301840 @default.
• W3035846598 cites W2607051840 @default.
• W3035846598 cites W2607261398 @default.
• W3035846598 cites W2612650514 @default.
• W3035846598 cites W2615774542 @default.
• W3035846598 cites W2617216694 @default.
• W3035846598 cites W2620016660 @default.
• W3035846598 cites W2737004789 @default.
• W3035846598 cites W2743249858 @default.
• W3035846598 cites W2756319919 @default.
• W3035846598 cites W2765772215 @default.
• W3035846598 cites W2768651426 @default.
• W3035846598 cites W2780075441 @default.
• W3035846598 cites W2781926475 @default.
• W3035846598 cites W2784614257 @default.
• W3035846598 cites W2785999368 @default.
• W3035846598 cites W2786318872 @default.
• W3035846598 cites W2786608785 @default.
• W3035846598 cites W2790649715 @default.
• W3035846598 cites W2791041386 @default.

• next