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• W3035856403 endingPage "140293" @default.
• W3035856403 startingPage "140293" @default.
• W3035856403 abstract "An increasing number of epidemiologic studies show that women have a special exposure profile to phthalates, and the exposures have attracted attention regarding their potential health hazards. Here, we developed a model for studying the ovarian action of di-(2-ethylhexyl) phthalate (DEHP) and its major metabolite monoethylhexyl phthalate (MEHP). In vivo, treatment with DEHP (250, 500, and 1000 mg kg^-1) induced decreased thickness of ovarian granulosa cell layer and mitochondrial damage in quail, caused oxidative stress, interfered with the transcription of hypothalamic-pituitary-ovarian axis (HPOA) steroid hormone-related factors (increased transcription of StAR, 3β-HSD, P450scc, and LH and decreased transcription of 17β-HSD, P450arom, FSH, and ERβ), and blocked the secretion of steroid hormones (decreased FSH, E2, and T levels and increased LH, P, and PRL levels). In vitro, granulosa cells were cultured with MEHP (50, 100, and 200 μM), activator of PPARγ (rosiglitazone, 50 μM), or antagonist of PPARγ (GW9662, 10 μM) for 24 h and gene and protein expression were analyzed by real time RT-PCR and western blot. Rosiglitazone, like MEHP, significantly decreased mRNA and protein levels of P450arom. Antagonist GW9662 partially blocked the suppression of P450arom by MEHP, suggesting that MEHP acts through PPARγ, but not exclusively. Our model shows that MEHP acts on granulosa cells in quail by stimulating PPARs, which leads to decreased gene and protein expression of P450arom. Therefore, the environmental endocrine disruptor DEHP and its major metabolite MEHP act through a receptor-mediated signaling pathway to inhibit the production of estradiol, interfere with the modulation of HPOA, suppress the synthesis of sex hormones, and cause sex hormone secretion disorders, resulting in severe toxicity in the female reproductive system. A framework for an adverse outcome pathway of DEHP/MEHP-induced ovarian toxicity was constructed, which can facilitate an improved understanding of the mechanism of female reproductive toxicity." @default.
• W3035856403 created "2020-06-25" @default.
• W3035856403 creator A5006003739 @default.
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• W3035856403 date "2020-11-01" @default.
• W3035856403 modified "2023-09-27" @default.
• W3035856403 title "Di-(2-ethylhexyl) phthalate induced developmental abnormalities of the ovary in quail (Coturnix japonica) via disruption of the hypothalamic-pituitary-ovarian axis" @default.
• W3035856403 cites W1562714112 @default.
• W3035856403 cites W1965680465 @default.
• W3035856403 cites W1972208841 @default.
• W3035856403 cites W1977970139 @default.
• W3035856403 cites W1989158173 @default.
• W3035856403 cites W1997744800 @default.
• W3035856403 cites W2002276672 @default.
• W3035856403 cites W2004763230 @default.
• W3035856403 cites W2015192043 @default.
• W3035856403 cites W2020880417 @default.
• W3035856403 cites W2024204031 @default.
• W3035856403 cites W2030574177 @default.
• W3035856403 cites W2036139206 @default.
• W3035856403 cites W2037269393 @default.
• W3035856403 cites W2041020481 @default.
• W3035856403 cites W2042050427 @default.
• W3035856403 cites W2051761727 @default.
• W3035856403 cites W2054003038 @default.
• W3035856403 cites W2065628842 @default.
• W3035856403 cites W2070969273 @default.
• W3035856403 cites W2072045475 @default.
• W3035856403 cites W2072271141 @default.
• W3035856403 cites W2078530840 @default.
• W3035856403 cites W2078711107 @default.
• W3035856403 cites W2089527604 @default.
• W3035856403 cites W2090098866 @default.
• W3035856403 cites W2095202170 @default.
• W3035856403 cites W2096248684 @default.
• W3035856403 cites W2100876394 @default.
• W3035856403 cites W2103562476 @default.
• W3035856403 cites W2107264043 @default.
• W3035856403 cites W2109055118 @default.
• W3035856403 cites W2142601658 @default.
• W3035856403 cites W2146542085 @default.
• W3035856403 cites W2148492226 @default.
• W3035856403 cites W2158478203 @default.
• W3035856403 cites W2161393867 @default.
• W3035856403 cites W2201971846 @default.
• W3035856403 cites W2270484212 @default.
• W3035856403 cites W2399040568 @default.
• W3035856403 cites W2443228351 @default.
• W3035856403 cites W2473487178 @default.
• W3035856403 cites W2512316953 @default.
• W3035856403 cites W2566968863 @default.
• W3035856403 cites W2605441944 @default.
• W3035856403 cites W2665650082 @default.
• W3035856403 cites W2742640224 @default.
• W3035856403 cites W2765795466 @default.
• W3035856403 cites W2769961049 @default.
• W3035856403 cites W2785768980 @default.
• W3035856403 cites W2792511415 @default.
• W3035856403 cites W2799517681 @default.
• W3035856403 cites W2806564438 @default.
• W3035856403 cites W2883071172 @default.
• W3035856403 cites W2890781920 @default.
• W3035856403 cites W2914629870 @default.
• W3035856403 cites W2920385976 @default.
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• W3035856403 cites W2954953292 @default.
• W3035856403 cites W2955579628 @default.
• W3035856403 cites W2993012387 @default.
• W3035856403 cites W2998405527 @default.
• W3035856403 cites W3001914730 @default.
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• W3035856403 doi "https://doi.org/10.1016/j.scitotenv.2020.140293" @default.
• W3035856403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32610232" @default.
• W3035856403 hasPublicationYear "2020" @default.
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