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- W3035860219 abstract "Significance Lck is critical for T cell development and activation, as it is the first kinase transducing TCR signaling. Lck can be bound or not bound (free) to the coreceptors (CD4 and CD8) in thymocytes and T cells. After comparing molecular properties of free and coreceptor-bound Lck, free Lck presents higher mobility and activity compared to the coreceptor-bound Lck. The coreceptor-Lck coupling is found to be independent of TCR activation. This information is valuable for better understanding the initiation of TCR signaling and the regulation of T cell sensitivity." @default.
- W3035860219 created "2020-06-25" @default.
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- W3035860219 date "2020-06-22" @default.
- W3035860219 modified "2023-10-15" @default.
- W3035860219 title "Lck bound to coreceptor is less active than free Lck" @default.
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- W3035860219 doi "https://doi.org/10.1073/pnas.1913334117" @default.
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