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- W3035866744 abstract "Damage to tendons occurs commonly during physical activity. Tendons can be repaired using natural and synthetic materials. The purpose of a tendon prosthesis is to provide support while allowing a new tendon to form. The newly formed tendon should have morphological and mechanical properties identical to the normal tissue. Neotendon formation can be assessed ultrastructurally to compare its morphology with that of mature tendon. The extent of cell ingrowth, collagen fibril diameter, proteoglycan (PG)/collagen interactions and collagen fibril bundle formation are all morphological criteria to evaluate the status of tendon repair. The purpose of this study is to ultrastructurally evaluate the mechanism by which a reconstituted collagen fiber tow is replaced by neotendon. Collagen fibers of the tow were prepared from insoluble type I collagen derived from bovine corium and crosslinked by severe dehydration followed by treatment with cyanamide, as previously described. A tow of 250 fibers was coated with a 1% type I collagen dispersion to form a thin ribbon prosthesis. Mature New Zealand white rabbits weighing 6-7 lbs were anesthetized and the Achilles tendon was removed and replaced with a sterile collagen fiber tow. At 3 and 10 weeks postoperatively the explants were fixed for conventional TEM and SEM as previously described." @default.
- W3035866744 created "2020-06-25" @default.
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- W3035866744 date "1989-08-06" @default.
- W3035866744 modified "2023-09-26" @default.
- W3035866744 title "Neotendon formation using a collagen fiber tendon prosthesis" @default.
- W3035866744 cites W2141514409 @default.
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- W3035866744 doi "https://doi.org/10.1017/s0424820100156389" @default.
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