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- W3035878085 endingPage "631" @default.
- W3035878085 startingPage "621" @default.
- W3035878085 abstract "Natural products generally fall into the biologically relevant chemical space and always possess novel biological activities, thus making them a rich source of lead compounds for new drug discovery. With the recent technological advances, natural product-based drug discovery is now reaching a new era. Natural products have also shown promise in epigenetic drug discovery, some of them have advanced into clinical trials or are presently being used in clinic. The histone lysine specific demethylase 1 (LSD1), an important class of histone demethylases, has fundamental roles in the development of various pathological conditions. Targeting LSD1 has been recognized as a promising therapeutic option for cancer treatment. Notably, some natural products with different chemotypes including protoberberine alkaloids, flavones, polyphenols, and cyclic peptides have shown effectiveness against LSD1. These natural products provide novel scaffolds for developing new LSD1 inhibitors. In this review, we mainly discuss the identification of natural LSD1 inhibitors, analysis of the co-crystal structures of LSD1/natural product complex, antitumor activity and their modes of action. We also briefly discuss the challenges faced in this field. We believe this review will provide a landscape of natural LSD1 inhibitors." @default.
- W3035878085 created "2020-06-25" @default.
- W3035878085 creator A5021788436 @default.
- W3035878085 creator A5032077091 @default.
- W3035878085 creator A5048423176 @default.
- W3035878085 creator A5050706812 @default.
- W3035878085 creator A5070238579 @default.
- W3035878085 creator A5070685116 @default.
- W3035878085 creator A5072183578 @default.
- W3035878085 date "2021-03-01" @default.
- W3035878085 modified "2023-10-13" @default.
- W3035878085 title "Natural products as LSD1 inhibitors for cancer therapy" @default.
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