FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035878445> ?p ?o ?g. }

• W3035878445 endingPage "280" @default.
• W3035878445 startingPage "275" @default.
• W3035878445 abstract "Abstract Aim Chromosome 8 open reading frame 46 (C8orf46), a human protein‐coding gene, has recently been named Vexin. A recent study indicated that Vexin is involved in embryonic neurogenesis. Additionally, some transcriptomic studies detected changes in the mRNA levels of patients with psychiatric and neurological diseases. In our previous study, we sought for target genes of brain‐derived neurotrophic factor (BDNF) in cultured rat cortical neurons, finding that BDNF potentially leads to the upregulation of Vexin mRNA. However, its underlying mechanisms are unknown. In the present study, we assessed the regulatory mechanisms of the BDNF‐induced gene expression of Vexin in vitro. Methods We reanalyzed ChIP‐seq data in various human organs provided by the ENCODE project, evaluating acetylation levels of the 27th lysine residue of the histone H3 (H3K27ac) at the Vexin locus. The transcriptomic effects of BDNF on rat Vexin (RGD1561849) were evaluated by real‐time quantitative PCR (RT‐qPCR) in primary cultures of cerebral cortical neurons, in the presence or absence of inhibitors for signaling molecules activated by BDNF. Results The Vexin locus and its promoter region in the brain angular gyrus show higher acetylation levels of the H3K27 than those in other organs. Stimulation of cultured rat cortical neurons, but not astrocyte, with BDNF, led to marked elevations in the mRNA levels of Vexin, which was inhibited in the presence of K252a and U0126. Conclusion The upregulated H3K27ac in the brain may be associated with the enriched gene expression of Vexin in the brain. It is indicated that BDNF induces the gene expression of Vexin in the cortical neurons via the TrkB‐MEK signaling pathway." @default.
• W3035878445 created "2020-06-25" @default.
• W3035878445 creator A5006626560 @default.
• W3035878445 creator A5017075337 @default.
• W3035878445 creator A5043042138 @default.
• W3035878445 creator A5057666700 @default.
• W3035878445 creator A5057681787 @default.
• W3035878445 creator A5066301741 @default.
• W3035878445 creator A5082008116 @default.
• W3035878445 creator A5084457844 @default.
• W3035878445 date "2020-06-19" @default.
• W3035878445 modified "2023-10-16" @default.
• W3035878445 title "Vexin is upregulated in cerebral cortical neurons by brain‐derived neurotrophic factor" @default.
• W3035878445 cites W1969885044 @default.
• W3035878445 cites W1979743168 @default.
• W3035878445 cites W1984203471 @default.
• W3035878445 cites W2021240205 @default.
• W3035878445 cites W2071466475 @default.
• W3035878445 cites W2083245183 @default.
• W3035878445 cites W2091146826 @default.
• W3035878445 cites W2117131162 @default.
• W3035878445 cites W2132369117 @default.
• W3035878445 cites W2160748841 @default.
• W3035878445 cites W2259938310 @default.
• W3035878445 cites W2576438521 @default.
• W3035878445 cites W2789603273 @default.
• W3035878445 cites W2790115161 @default.
• W3035878445 doi "https://doi.org/10.1002/npr2.12119" @default.
• W3035878445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7722677" @default.
• W3035878445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32558188" @default.
• W3035878445 hasPublicationYear "2020" @default.
• W3035878445 type Work @default.
• W3035878445 sameAs 3035878445 @default.
• W3035878445 citedByCount "2" @default.
• W3035878445 countsByYear W30358784452021 @default.
• W3035878445 countsByYear W30358784452022 @default.
• W3035878445 crossrefType "journal-article" @default.
• W3035878445 hasAuthorship W3035878445A5006626560 @default.
• W3035878445 hasAuthorship W3035878445A5017075337 @default.
• W3035878445 hasAuthorship W3035878445A5043042138 @default.
• W3035878445 hasAuthorship W3035878445A5057666700 @default.
• W3035878445 hasAuthorship W3035878445A5057681787 @default.
• W3035878445 hasAuthorship W3035878445A5066301741 @default.
• W3035878445 hasAuthorship W3035878445A5082008116 @default.
• W3035878445 hasAuthorship W3035878445A5084457844 @default.
• W3035878445 hasBestOaLocation W30358784451 @default.
• W3035878445 hasConcept C104317684 @default.
• W3035878445 hasConcept C127561419 @default.
• W3035878445 hasConcept C150194340 @default.
• W3035878445 hasConcept C160539049 @default.
• W3035878445 hasConcept C162317418 @default.
• W3035878445 hasConcept C169760540 @default.
• W3035878445 hasConcept C170493617 @default.
• W3035878445 hasConcept C2778790584 @default.
• W3035878445 hasConcept C4746552 @default.
• W3035878445 hasConcept C54355233 @default.
• W3035878445 hasConcept C86803240 @default.
• W3035878445 hasConcept C95444343 @default.
• W3035878445 hasConceptScore W3035878445C104317684 @default.
• W3035878445 hasConceptScore W3035878445C127561419 @default.
• W3035878445 hasConceptScore W3035878445C150194340 @default.
• W3035878445 hasConceptScore W3035878445C160539049 @default.
• W3035878445 hasConceptScore W3035878445C162317418 @default.
• W3035878445 hasConceptScore W3035878445C169760540 @default.
• W3035878445 hasConceptScore W3035878445C170493617 @default.
• W3035878445 hasConceptScore W3035878445C2778790584 @default.
• W3035878445 hasConceptScore W3035878445C4746552 @default.
• W3035878445 hasConceptScore W3035878445C54355233 @default.
• W3035878445 hasConceptScore W3035878445C86803240 @default.
• W3035878445 hasConceptScore W3035878445C95444343 @default.
• W3035878445 hasFunder F4320320912 @default.
• W3035878445 hasIssue "3" @default.
• W3035878445 hasLocation W30358784451 @default.
• W3035878445 hasLocation W30358784452 @default.
• W3035878445 hasLocation W30358784453 @default.
• W3035878445 hasOpenAccess W3035878445 @default.
• W3035878445 hasPrimaryLocation W30358784451 @default.
• W3035878445 hasRelatedWork W1491081574 @default.
• W3035878445 hasRelatedWork W1593725384 @default.
• W3035878445 hasRelatedWork W2009966535 @default.
• W3035878445 hasRelatedWork W2039959685 @default.
• W3035878445 hasRelatedWork W2096180958 @default.
• W3035878445 hasRelatedWork W2111443630 @default.
• W3035878445 hasRelatedWork W2360504692 @default.
• W3035878445 hasRelatedWork W2376928626 @default.
• W3035878445 hasRelatedWork W3034674859 @default.
• W3035878445 hasRelatedWork W4378740640 @default.
• W3035878445 hasVolume "40" @default.
• W3035878445 isParatext "false" @default.
• W3035878445 isRetracted "false" @default.
• W3035878445 magId "3035878445" @default.
• W3035878445 workType "article" @default.