FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035893178> ?p ?o ?g. }

• W3035893178 endingPage "110425" @default.
• W3035893178 startingPage "110425" @default.
• W3035893178 abstract "Acute leukemia is a common hematological malignancy. Despite recent promising progress, the prognosis of acute leukemia patients remains to be improved. New therapies are therefore still needed. Salmonella typhimurium has been shown to be highly effective as an anti-tumor agent in many solid cancer models, but it has not been applied in acute leukemia. Here, we report an attenuated Salmonella typhimurium strain, VNP20009, can induce apoptosis in multiple types of leukemia cells both in vivo and in vitro. Furthermore, VNP20009 significantly inhibited the proliferation of MLL-AF9-induced acute myeloid leukemia cells and prolonged the survival of the AML-carrying mice. VNP20009 restored the counts of white blood cell (WBC) and its five subsets in peripheral blood (PB) to near-physiological values, and elevated the levels of certain cytokines, such as tumor necrosis factor-α (TNF-α), leukemia inhibitory factor (LIF), interferon-γ (IFN-γ), chemokine C-X-C motif ligand-10 (CXCL-10) and C-C motif ligand-2 (CCL-2). Moreover, the ratio of immune cells, including natural killer cells (NKs), CD4+ Th1-type cells and CD8+ IFN-γ-producing effector T cells were highly upregulated in the AML mice treated with VNP20009. The results of the present study potentially provide an alternative therapeutic strategy for hematologic malignancies through boosting the innate and adaptive anti-tumor immunity." @default.
• W3035893178 created "2020-06-25" @default.
• W3035893178 creator A5011137062 @default.
• W3035893178 creator A5020480328 @default.
• W3035893178 creator A5023599471 @default.
• W3035893178 creator A5024902545 @default.
• W3035893178 creator A5036315860 @default.
• W3035893178 creator A5038263452 @default.
• W3035893178 creator A5041671934 @default.
• W3035893178 creator A5053599896 @default.
• W3035893178 creator A5060879223 @default.
• W3035893178 creator A5063180530 @default.
• W3035893178 creator A5066689255 @default.
• W3035893178 creator A5072559250 @default.
• W3035893178 creator A5086024745 @default.
• W3035893178 date "2020-09-01" @default.
• W3035893178 modified "2023-10-17" @default.
• W3035893178 title "Inhibition of acute leukemia with attenuated Salmonella typhimurium strain VNP20009" @default.
• W3035893178 cites W1558704041 @default.
• W3035893178 cites W1831756640 @default.
• W3035893178 cites W1968810589 @default.
• W3035893178 cites W1978796754 @default.
• W3035893178 cites W1979507175 @default.
• W3035893178 cites W2009770467 @default.
• W3035893178 cites W2029243931 @default.
• W3035893178 cites W2042699075 @default.
• W3035893178 cites W2048802346 @default.
• W3035893178 cites W2064422200 @default.
• W3035893178 cites W2077015232 @default.
• W3035893178 cites W2084586968 @default.
• W3035893178 cites W2088592373 @default.
• W3035893178 cites W2094650342 @default.
• W3035893178 cites W2099472238 @default.
• W3035893178 cites W2103773341 @default.
• W3035893178 cites W2105548768 @default.
• W3035893178 cites W2112010454 @default.
• W3035893178 cites W2115205513 @default.
• W3035893178 cites W2118817451 @default.
• W3035893178 cites W2153827649 @default.
• W3035893178 cites W2168437161 @default.
• W3035893178 cites W2341620281 @default.
• W3035893178 cites W2557760581 @default.
• W3035893178 cites W2617691667 @default.
• W3035893178 cites W2732632787 @default.
• W3035893178 cites W2753602919 @default.
• W3035893178 cites W2779167403 @default.
• W3035893178 cites W2890593096 @default.
• W3035893178 cites W2905644126 @default.
• W3035893178 cites W2998493318 @default.
• W3035893178 cites W4242852378 @default.
• W3035893178 doi "https://doi.org/10.1016/j.biopha.2020.110425" @default.
• W3035893178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32570123" @default.
• W3035893178 hasPublicationYear "2020" @default.
• W3035893178 type Work @default.
• W3035893178 sameAs 3035893178 @default.
• W3035893178 citedByCount "8" @default.
• W3035893178 countsByYear W30358931782022 @default.
• W3035893178 countsByYear W30358931782023 @default.
• W3035893178 crossrefType "journal-article" @default.
• W3035893178 hasAuthorship W3035893178A5011137062 @default.
• W3035893178 hasAuthorship W3035893178A5020480328 @default.
• W3035893178 hasAuthorship W3035893178A5023599471 @default.
• W3035893178 hasAuthorship W3035893178A5024902545 @default.
• W3035893178 hasAuthorship W3035893178A5036315860 @default.
• W3035893178 hasAuthorship W3035893178A5038263452 @default.
• W3035893178 hasAuthorship W3035893178A5041671934 @default.
• W3035893178 hasAuthorship W3035893178A5053599896 @default.
• W3035893178 hasAuthorship W3035893178A5060879223 @default.
• W3035893178 hasAuthorship W3035893178A5063180530 @default.
• W3035893178 hasAuthorship W3035893178A5066689255 @default.
• W3035893178 hasAuthorship W3035893178A5072559250 @default.
• W3035893178 hasAuthorship W3035893178A5086024745 @default.
• W3035893178 hasBestOaLocation W30358931781 @default.
• W3035893178 hasConcept C136449434 @default.
• W3035893178 hasConcept C167672396 @default.
• W3035893178 hasConcept C17991360 @default.
• W3035893178 hasConcept C203014093 @default.
• W3035893178 hasConcept C2776863199 @default.
• W3035893178 hasConcept C2778461978 @default.
• W3035893178 hasConcept C2778690821 @default.
• W3035893178 hasConcept C2778729363 @default.
• W3035893178 hasConcept C502942594 @default.
• W3035893178 hasConcept C71924100 @default.
• W3035893178 hasConcept C86803240 @default.
• W3035893178 hasConcept C8891405 @default.
• W3035893178 hasConceptScore W3035893178C136449434 @default.
• W3035893178 hasConceptScore W3035893178C167672396 @default.
• W3035893178 hasConceptScore W3035893178C17991360 @default.
• W3035893178 hasConceptScore W3035893178C203014093 @default.
• W3035893178 hasConceptScore W3035893178C2776863199 @default.
• W3035893178 hasConceptScore W3035893178C2778461978 @default.
• W3035893178 hasConceptScore W3035893178C2778690821 @default.
• W3035893178 hasConceptScore W3035893178C2778729363 @default.
• W3035893178 hasConceptScore W3035893178C502942594 @default.
• W3035893178 hasConceptScore W3035893178C71924100 @default.
• W3035893178 hasConceptScore W3035893178C86803240 @default.
• W3035893178 hasConceptScore W3035893178C8891405 @default.
• W3035893178 hasFunder F4320321001 @default.

• next