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- W3035895802 abstract "The present COVID-19 pandemic was initiated in December 2019 in Wuhan (China) and rapidly extended to become a global sanitary and economic emergency. Its etiological agent is the coronavirus SARS-Cov-2. COVID-19 presents a wide spectrum of clinical manifestations, that go from an asymptomatic infection to a severe pneumonia accompanied by multisystemic failure leading to patient´s death. The immune response to SARS-CoV-2 is known to involve all the components of the immune system that all together appear responsible for viral elimination and recovery from the Infection. Nonetheless, such immune responses are implicated in the progress of the disease to a more severe and lethal process. This review describes the general aspects of both COVID-19, and its etiological agent SARS-CoV-2, stressing the similarities with other severe coronavirus infections, such SARS and MERS, but more importantly, pointing towards the evidences supporting the hypothesis that the clinical spectrum of COVID-19 is the consequence of the corresponding variable spectrum of the immune responses to the virus. The critical point where progression of the disease ensues appears to center in loss of the immune regulation between a protective response and an altered response due to exacerbation of the inflammatory component. Finally, it appears possible to delineate certain major challenges that should be intensively investigated to further understand COVID-19 immunopathogenesis, thus helping to design more effective diagnostic, therapeutic and prophylactic strategies" @default.
- W3035895802 created "2020-06-25" @default.
- W3035895802 creator A5047989235 @default.
- W3035895802 date "2020-06-16" @default.
- W3035895802 modified "2023-10-16" @default.
- W3035895802 title "Immune Response, Inflammation, and the Clinical Spectrum of COVID-19" @default.
- W3035895802 cites W1570518673 @default.
- W3035895802 cites W1594981111 @default.
- W3035895802 cites W1662940398 @default.
- W3035895802 cites W1823673912 @default.
- W3035895802 cites W1922712900 @default.
- W3035895802 cites W1933155703 @default.
- W3035895802 cites W1935746582 @default.
- W3035895802 cites W1964982019 @default.
- W3035895802 cites W1994553843 @default.
- W3035895802 cites W1995481571 @default.
- W3035895802 cites W2006192795 @default.
- W3035895802 cites W2007882491 @default.
- W3035895802 cites W2012770524 @default.
- W3035895802 cites W2016029872 @default.
- W3035895802 cites W2044518292 @default.
- W3035895802 cites W2058780476 @default.
- W3035895802 cites W2065307239 @default.
- W3035895802 cites W2072522367 @default.
- W3035895802 cites W2074963908 @default.
- W3035895802 cites W2091671824 @default.
- W3035895802 cites W2105626573 @default.
- W3035895802 cites W2111058723 @default.
- W3035895802 cites W2113391111 @default.
- W3035895802 cites W2118612771 @default.
- W3035895802 cites W2122691845 @default.
- W3035895802 cites W2124259324 @default.
- W3035895802 cites W2135264287 @default.
- W3035895802 cites W2151957195 @default.
- W3035895802 cites W2152877666 @default.
- W3035895802 cites W2158118659 @default.
- W3035895802 cites W2159823033 @default.
- W3035895802 cites W2160534673 @default.
- W3035895802 cites W2167384912 @default.
- W3035895802 cites W2171330205 @default.
- W3035895802 cites W2256430766 @default.
- W3035895802 cites W2610356532 @default.
- W3035895802 cites W2742905047 @default.
- W3035895802 cites W2913776187 @default.
- W3035895802 cites W2942615395 @default.
- W3035895802 cites W2953275535 @default.
- W3035895802 cites W2995449088 @default.
- W3035895802 cites W3001118548 @default.
- W3035895802 cites W3001456238 @default.
- W3035895802 cites W3001638293 @default.
- W3035895802 cites W3002108456 @default.
- W3035895802 cites W3003217347 @default.
- W3035895802 cites W3003668884 @default.
- W3035895802 cites W3004280078 @default.
- W3035895802 cites W3006594788 @default.
- W3035895802 cites W3007257464 @default.
- W3035895802 cites W3007643904 @default.
- W3035895802 cites W3007831031 @default.
- W3035895802 cites W3007929363 @default.
- W3035895802 cites W3007940623 @default.
- W3035895802 cites W3008394341 @default.
- W3035895802 cites W3008649550 @default.
- W3035895802 cites W3008827533 @default.
- W3035895802 cites W3008869844 @default.
- W3035895802 cites W3008928028 @default.
- W3035895802 cites W3008954191 @default.
- W3035895802 cites W3009109635 @default.
- W3035895802 cites W3009335299 @default.
- W3035895802 cites W3009437769 @default.
- W3035895802 cites W3009468976 @default.
- W3035895802 cites W3009849619 @default.
- W3035895802 cites W3009912996 @default.
- W3035895802 cites W3010198307 @default.
- W3035895802 cites W3010441732 @default.
- W3035895802 cites W3010592738 @default.
- W3035895802 cites W3011017798 @default.
- W3035895802 cites W3011093535 @default.
- W3035895802 cites W3011127849 @default.
- W3035895802 cites W3011224398 @default.
- W3035895802 cites W3011230498 @default.
- W3035895802 cites W3011379523 @default.
- W3035895802 cites W3011421089 @default.
- W3035895802 cites W3011488280 @default.
- W3035895802 cites W3011492172 @default.
- W3035895802 cites W3011508332 @default.
- W3035895802 cites W3011537081 @default.
- W3035895802 cites W3011586138 @default.
- W3035895802 cites W3011610993 @default.
- W3035895802 cites W3011792889 @default.
- W3035895802 cites W3012088820 @default.
- W3035895802 cites W3012134879 @default.
- W3035895802 cites W3012180666 @default.
- W3035895802 cites W3012253443 @default.
- W3035895802 cites W3012284084 @default.
- W3035895802 cites W3012345473 @default.
- W3035895802 cites W3012421327 @default.
- W3035895802 cites W3012540309 @default.
- W3035895802 cites W3012696170 @default.
- W3035895802 cites W3012797451 @default.
- W3035895802 cites W3012846954 @default.