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- W3035915002 abstract "Abstract Cardiorespiratory fitness (CRF) and endurance performance are characterized by a complex genetic trait with high heritability. Although research has identified many physiological and environmental correlates with CRF, the genetic architecture contributing to CRF remains unclear, especially in non-athlete population. A total of 762 Chinese young female participants were recruited and an endurance run test was used to determine CRF. We used a fixed model of genome-wide association studies (GWAS) for CRF. Genotyping was performed using the Affymetrix Axiom and illumina 1 M arrays. After quality control and imputation, a linear regression-based association analysis was conducted using a total of 5,149,327 variants. Four loci associated with CRF were identified to reach genome-wide significance (P < 5.0 × 10 -8 ), which located in 15q21.3 (rs17240160, P = 1.73 × 10 -9 , GCOM1), 3q25.31 (rs819865, P = 8.56 × 10 -9 , GMPS), 21q22.3 (rs117828698, P = 9.59 × 10 -9 , COL18A1), and 17q24.2 (rs79806428, P = 3.85 × 10 -8 , PRKCA). These loci (GCOM1, GMPS, COL18A1 and PRKCA) associated with cardiorespiratory fitness and endurance performance in Chinese non-athlete young females. Our results suggest that these gene polymorphisms provide further genetic evidence for the polygenetic nature of cardiorespiratory endurance and be used as genetic biomarkers for future research." @default.
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- W3035915002 date "2020-06-22" @default.
- W3035915002 modified "2023-09-27" @default.
- W3035915002 title "Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females" @default.
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- W3035915002 doi "https://doi.org/10.1038/s41598-020-67045-y" @default.
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