Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035927989> ?p ?o ?g. }
- W3035927989 abstract "Abstract Feed efficiency (FE) is an important trait in the porcine industry. Therefore, understanding the molecular mechanisms of FE is vital for the improvement of this trait. In this study, 6 extreme high-FE and 6 low-FE pigs were selected from 225 Duroc × (Landrace × Yorkshire) (DLY) pigs for transcriptomic analysis. RNA-seq analysis was performed to determine differentially expressed genes (DEGs) in the liver tissues of the 12 individuals, and 507 DEGs were identified between high-FE pigs (HE- group) and low-FE pigs (LE- group). A gene ontology (GO) enrichment and pathway enrichment analysis were performed and revealed that glycolytic metabolism and lipid synthesis-related pathways were significantly enriched within DEGs; all of these DEGs were downregulated in the HE- group. Moreover, Weighted gene co-expression analysis (WGCNA) revealed that oxidative phosphorylation, thermogenesis, and energy metabolism-related pathways were negatively related to HE- group, which might result in lower energy consumption in higher efficiency pigs. These results implied that the higher FE in the HE- group may be attributed to a lower glycolytic, energy consumption and lipid synthesizing potential in the liver. Furthermore, our findings suggested that the inhibition of lipid synthesis and glucose metabolic activity in the liver may be strategies for improving the FE of DLY pigs." @default.
- W3035927989 created "2020-06-25" @default.
- W3035927989 creator A5005710285 @default.
- W3035927989 creator A5017035775 @default.
- W3035927989 creator A5020879747 @default.
- W3035927989 creator A5024789097 @default.
- W3035927989 creator A5041745227 @default.
- W3035927989 creator A5045584745 @default.
- W3035927989 creator A5047354889 @default.
- W3035927989 creator A5055233272 @default.
- W3035927989 creator A5059772228 @default.
- W3035927989 creator A5060141742 @default.
- W3035927989 creator A5061908529 @default.
- W3035927989 creator A5070918040 @default.
- W3035927989 date "2020-06-18" @default.
- W3035927989 modified "2023-10-16" @default.
- W3035927989 title "A Transcriptome Analysis Reveals that Hepatic Glycolysis and Lipid Synthesis Are Negatively Associated with Feed Efficiency in DLY Pigs" @default.
- W3035927989 cites W1503760388 @default.
- W3035927989 cites W1912998182 @default.
- W3035927989 cites W1966229938 @default.
- W3035927989 cites W1966327575 @default.
- W3035927989 cites W1973996769 @default.
- W3035927989 cites W1974413554 @default.
- W3035927989 cites W1975538737 @default.
- W3035927989 cites W1984708728 @default.
- W3035927989 cites W1984868409 @default.
- W3035927989 cites W1987014914 @default.
- W3035927989 cites W1995057032 @default.
- W3035927989 cites W2000508414 @default.
- W3035927989 cites W2000602334 @default.
- W3035927989 cites W2022525264 @default.
- W3035927989 cites W2027847170 @default.
- W3035927989 cites W2035618305 @default.
- W3035927989 cites W2038124238 @default.
- W3035927989 cites W2039837718 @default.
- W3035927989 cites W2044842369 @default.
- W3035927989 cites W2045387309 @default.
- W3035927989 cites W2046645216 @default.
- W3035927989 cites W2084212236 @default.
- W3035927989 cites W2085584532 @default.
- W3035927989 cites W2094107051 @default.
- W3035927989 cites W2097929428 @default.
- W3035927989 cites W2099623630 @default.
- W3035927989 cites W2114570899 @default.
- W3035927989 cites W2122031129 @default.
- W3035927989 cites W2123708355 @default.
- W3035927989 cites W2134526812 @default.
- W3035927989 cites W2146516445 @default.
- W3035927989 cites W2150910996 @default.
- W3035927989 cites W2155839154 @default.
- W3035927989 cites W2157371286 @default.
- W3035927989 cites W2159675211 @default.
- W3035927989 cites W2169456326 @default.
- W3035927989 cites W2197990644 @default.
- W3035927989 cites W2202100154 @default.
- W3035927989 cites W2256781010 @default.
- W3035927989 cites W2289161090 @default.
- W3035927989 cites W2315834011 @default.
- W3035927989 cites W2417547881 @default.
- W3035927989 cites W2467814536 @default.
- W3035927989 cites W2518178890 @default.
- W3035927989 cites W2522099942 @default.
- W3035927989 cites W2599933185 @default.
- W3035927989 cites W2601298138 @default.
- W3035927989 cites W2613638837 @default.
- W3035927989 cites W2626425769 @default.
- W3035927989 cites W2740094125 @default.
- W3035927989 cites W2747238344 @default.
- W3035927989 cites W2765417393 @default.
- W3035927989 cites W2782502720 @default.
- W3035927989 cites W2801637253 @default.
- W3035927989 cites W2805432147 @default.
- W3035927989 cites W2914920169 @default.
- W3035927989 cites W2917791795 @default.
- W3035927989 cites W2930493222 @default.
- W3035927989 cites W4238035298 @default.
- W3035927989 cites W71047797 @default.
- W3035927989 doi "https://doi.org/10.1038/s41598-020-66988-6" @default.
- W3035927989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7303214" @default.
- W3035927989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32555275" @default.
- W3035927989 hasPublicationYear "2020" @default.
- W3035927989 type Work @default.
- W3035927989 sameAs 3035927989 @default.
- W3035927989 citedByCount "8" @default.
- W3035927989 countsByYear W30359279892021 @default.
- W3035927989 countsByYear W30359279892022 @default.
- W3035927989 countsByYear W30359279892023 @default.
- W3035927989 crossrefType "journal-article" @default.
- W3035927989 hasAuthorship W3035927989A5005710285 @default.
- W3035927989 hasAuthorship W3035927989A5017035775 @default.
- W3035927989 hasAuthorship W3035927989A5020879747 @default.
- W3035927989 hasAuthorship W3035927989A5024789097 @default.
- W3035927989 hasAuthorship W3035927989A5041745227 @default.
- W3035927989 hasAuthorship W3035927989A5045584745 @default.
- W3035927989 hasAuthorship W3035927989A5047354889 @default.
- W3035927989 hasAuthorship W3035927989A5055233272 @default.
- W3035927989 hasAuthorship W3035927989A5059772228 @default.
- W3035927989 hasAuthorship W3035927989A5060141742 @default.
- W3035927989 hasAuthorship W3035927989A5061908529 @default.
- W3035927989 hasAuthorship W3035927989A5070918040 @default.