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- W3035935625 abstract "Unlike other animal species, the dog is relatively resistent to develop hypercholesterolemia and atheromatous lesions even after long periods of cholesterol feeding. This difficulty is, however, eliminated if the thyroid activity is suppressed surgically or pharmacologically. The most common procedure employed is thiouracil administration. During the course of our studies on the response of the vascular wall to various stimuli, it was of interest to assess the possible effects of thiouracil on the mural elements, since information on the subject is almost nonexistent. In this presentation reference will be made only to changes of the internal elastic lamina (IEL) observed in the carotid and femoral arteries of two mongrel young dogs fed purina chow supplemented by thiouracil (100/mg/kg/day) for 3 and 6 months respectively. The earliest change appeared to consist of an accentuation of the filamentous components of the IEL, formation of fissures or clefts partially filled with a fine fibrillar electron dense material (Fig. 1), and loose bundles of collagen fibrils (Fig. 2). At a later stage, large areas of IEL have a “spongy” appearance with numerous clefts and rarefied areas present." @default.
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- W3035935625 date "1971-08-01" @default.
- W3035935625 modified "2023-10-18" @default.
- W3035935625 title "Thiouracil-Induced Elastic Tissue Degenerative Changes in Canine Arteries" @default.
- W3035935625 cites W120756454 @default.
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- W3035935625 doi "https://doi.org/10.1017/s0424820100066899" @default.
- W3035935625 hasPublicationYear "1971" @default.
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