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- W3035937945 abstract "Several models have been proposed for the functional organization of RNA within the eukaryotic nucleus and for the relationship of this organization to the distribution of pre-mRNA splicing factors. One model suggests that RNAs which must be spliced are capable of recruiting splicing factors to the sites of transcription from storage and/or reassembly sites. In order to further evaluate this model we have transiently transfected HeLa cells with constructs which express RNA transcripts containing introns, lacking introns, or containing an intron with a deletion at the 3' splice site. The expression of RNAs was detected by in situ hybridization and their association with splicing factors was evaluated by immunostaining using specific antibodies (Y12, SC35) in the same cells. We have found that the majority of the RNA transcripts produced from constructs which express intron-containing genes such as β-globin, tropomyosin, and HIV tat are associated with splicing factors. In contrast, RNAs lacking introns, such as βgalactosidase, and adenovirus VAI, are not associated with splicing factors in the nucleus." @default.
- W3035937945 created "2020-06-25" @default.
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- W3035937945 date "1995-08-13" @default.
- W3035937945 modified "2023-09-26" @default.
- W3035937945 title "The functional organization of RNAs in the mammalian cell nucleus" @default.
- W3035937945 cites W1964629933 @default.
- W3035937945 doi "https://doi.org/10.1017/s0424820100140129" @default.
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