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- W3035953876 abstract "Exhaled breath condensate (EBC) analysis is a rapidly growing field of researchand may be a useful non-invasive technique to evaluate lung pathology. There is littleinformation in the literature on the safety of collecting these samples in acutely ill infantsneeding mechanical ventilation. Viral bronchiolitis is a common lower respiratory tractinfection contributing to the majority of hospitalizations in children under 2 years ofage. The pathophysiology of severe bronchiolitis resulting in ventilatory support is illdefined.Our study objective was to evaluate the tolerability of collection and utilityof exhaled breath condensate (EBC) in molecular evaluation of viral bronchiolitis.We obtained proteomic profile of sequential EBCs over three days of illness fromtwo infants who were intubated and ventilated. Mass spectrometry analysis of thesesamples identified cytokeratin at all time-points and time-dependent increase ofproteins related to intracellular adhesions, epidermal morphogenesis, cell repair anddifferentiation that may be used to monitor the status of epithelial barrier functionand integrity of intercellular communication in the bronchiolitis lung in the future.Our pilot study highlights that EBC collection is a well- tolerated procedure to obtainmeaningful longitudinal data to profile and study the molecular parameters in acutelyill bronchiolitis infants." @default.
- W3035953876 created "2020-06-25" @default.
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- W3035953876 date "2020-02-06" @default.
- W3035953876 modified "2023-09-24" @default.
- W3035953876 title "Safety and Yield of Exhaled Breath Condensate Analysis in Acutely Ill, Mechanically Ventilated Infants with RSV Bronchiolitis" @default.
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- W3035953876 doi "https://doi.org/10.26717/bjstr.2020.25.004198" @default.
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