Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035964844> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3035964844 abstract "Background: Hyoscine N-butylbromide (Buscopan) is clinically used as an anticholinergic antispasmodic for the treatment of abdominal cramping or visceral pain associated with cramps.Objectives: we aimed to study the effect of pretreatment by a single injection of various doses of Hyoscin N-butylbromide (HBB) (1mg/Kg, 2.5mg/Kg and 5mg/Kg), on changes in gastric contents in pyloric ligated rats receiving indomethacin in a dose of 100mg/Kg i.p, and on gastric ulcer formation induced in rats by the same dose of indomethacin and subjected to restraint stress.Materials and Methods: This study was conducted on 60 adult male albino rats, divided into two equal categories, which were further divided into five equal subgroups.Results: Administration of HBB in doses of 1mg/Kg (i.p) to rats subjected to restraint stress and indomethacin administration in a dose of 100mg/kg led to insignificant decrease in the gastric ulcer index relative to the group received indomethacin and subjected to restraint stress with a protection ratio of (3%). Administration of HBB in doses of 2.5mg/Kg and 5mg/Kg (i.p) to rats subjected to restraint stress and indomethacin administration in a dose of 100mg/kg led to a significant decrease in the gastric ulcer index relative the group received indomethacin and subjected to restraint stress with a protection ratio of 60.46% and 66.41% respectively. Administration of HBB in doses of 1mg/Kg, 2.5mg/Kg and 5mg/Kg (i.p) to pyloric-ligated rats led to a significant decrease in gastric juice volume, acid concentration and the total acid output compared to the group receiving indomethacin.Conclusion: Intraperitoneal administration of HBB in doses of 1mg/Kg, 2.5mg/Kg and 5mg/Kg to rats in a dose-dependent manner led to a prophylactic effect against stress induced gastric ulcers, with a protection ratio of 3%, 60.46% and 66.41% respectively." @default.
- W3035964844 created "2020-06-25" @default.
- W3035964844 creator A5028926311 @default.
- W3035964844 creator A5052067751 @default.
- W3035964844 creator A5066634893 @default.
- W3035964844 creator A5076761032 @default.
- W3035964844 date "2018-04-01" @default.
- W3035964844 modified "2023-09-23" @default.
- W3035964844 title "EFFECT OF HYOSCIN N-BUTYL BROMIDE ON GASTRIC ULCERATION INDUCED BY INDOMETHACIN AND RESTRAINT STRESS, AND ON GASTRIC SECRETION IN ADULT MALE ALBINO RATS" @default.
- W3035964844 cites W1573354163 @default.
- W3035964844 cites W1662200088 @default.
- W3035964844 cites W1967825926 @default.
- W3035964844 cites W1981049802 @default.
- W3035964844 cites W1986339826 @default.
- W3035964844 cites W1990425813 @default.
- W3035964844 cites W2004189807 @default.
- W3035964844 cites W2046393976 @default.
- W3035964844 cites W2048946063 @default.
- W3035964844 cites W2054648256 @default.
- W3035964844 cites W2056371599 @default.
- W3035964844 cites W2084075822 @default.
- W3035964844 cites W2088333586 @default.
- W3035964844 cites W2106546953 @default.
- W3035964844 cites W2121082147 @default.
- W3035964844 cites W2127279432 @default.
- W3035964844 cites W2155042408 @default.
- W3035964844 cites W2169768464 @default.
- W3035964844 cites W2303730293 @default.
- W3035964844 doi "https://doi.org/10.12816/0052267" @default.
- W3035964844 hasPublicationYear "2018" @default.
- W3035964844 type Work @default.
- W3035964844 sameAs 3035964844 @default.
- W3035964844 citedByCount "0" @default.
- W3035964844 crossrefType "journal-article" @default.
- W3035964844 hasAuthorship W3035964844A5028926311 @default.
- W3035964844 hasAuthorship W3035964844A5052067751 @default.
- W3035964844 hasAuthorship W3035964844A5066634893 @default.
- W3035964844 hasAuthorship W3035964844A5076761032 @default.
- W3035964844 hasBestOaLocation W30359648441 @default.
- W3035964844 hasConcept C126322002 @default.
- W3035964844 hasConcept C2776672619 @default.
- W3035964844 hasConcept C2776798904 @default.
- W3035964844 hasConcept C2777504413 @default.
- W3035964844 hasConcept C2778689640 @default.
- W3035964844 hasConcept C2779422922 @default.
- W3035964844 hasConcept C2780073392 @default.
- W3035964844 hasConcept C2781443798 @default.
- W3035964844 hasConcept C42219234 @default.
- W3035964844 hasConcept C71924100 @default.
- W3035964844 hasConcept C90924648 @default.
- W3035964844 hasConcept C98274493 @default.
- W3035964844 hasConceptScore W3035964844C126322002 @default.
- W3035964844 hasConceptScore W3035964844C2776672619 @default.
- W3035964844 hasConceptScore W3035964844C2776798904 @default.
- W3035964844 hasConceptScore W3035964844C2777504413 @default.
- W3035964844 hasConceptScore W3035964844C2778689640 @default.
- W3035964844 hasConceptScore W3035964844C2779422922 @default.
- W3035964844 hasConceptScore W3035964844C2780073392 @default.
- W3035964844 hasConceptScore W3035964844C2781443798 @default.
- W3035964844 hasConceptScore W3035964844C42219234 @default.
- W3035964844 hasConceptScore W3035964844C71924100 @default.
- W3035964844 hasConceptScore W3035964844C90924648 @default.
- W3035964844 hasConceptScore W3035964844C98274493 @default.
- W3035964844 hasLocation W30359648441 @default.
- W3035964844 hasOpenAccess W3035964844 @default.
- W3035964844 hasPrimaryLocation W30359648441 @default.
- W3035964844 hasRelatedWork W157812000 @default.
- W3035964844 hasRelatedWork W176240926 @default.
- W3035964844 hasRelatedWork W2001991510 @default.
- W3035964844 hasRelatedWork W2046555336 @default.
- W3035964844 hasRelatedWork W2059903366 @default.
- W3035964844 hasRelatedWork W2084453741 @default.
- W3035964844 hasRelatedWork W2085444653 @default.
- W3035964844 hasRelatedWork W2316705764 @default.
- W3035964844 hasRelatedWork W2321897891 @default.
- W3035964844 hasRelatedWork W2324883330 @default.
- W3035964844 hasRelatedWork W2409793110 @default.
- W3035964844 hasRelatedWork W2419107048 @default.
- W3035964844 hasRelatedWork W2550160667 @default.
- W3035964844 hasRelatedWork W2989020746 @default.
- W3035964844 hasRelatedWork W2993413762 @default.
- W3035964844 hasRelatedWork W3096801835 @default.
- W3035964844 hasRelatedWork W3108626639 @default.
- W3035964844 hasRelatedWork W3184210175 @default.
- W3035964844 hasRelatedWork W2182899154 @default.
- W3035964844 hasRelatedWork W2833508626 @default.
- W3035964844 isParatext "false" @default.
- W3035964844 isRetracted "false" @default.
- W3035964844 magId "3035964844" @default.
- W3035964844 workType "article" @default.