FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036007768> ?p ?o ?g. }

• W3036007768 endingPage "72" @default.
• W3036007768 startingPage "59" @default.
• W3036007768 abstract "Methylation of the N6 position of adenosine (m6A) is a widespread RNA modification that is critical for various physiological and pathological processes. Although this modification was also found in the RNA of several viruses almost 40 years ago, its biological functions during viral infection have been elucidated recently. Here, we investigated the effects of viral and host RNA methylation during porcine epidemic diarrhea virus (PEDV) infection. The results demonstrated that the m6A modification was abundant in the PEDV genome and the host methyltransferases METTL3 and METTL14 and demethylase FTO were involved in the regulation of viral replication. The knockdown of the methyltransferases increased PEDV replication while silencing the demethylase decreased PEDV output. Moreover, the proteins of the YTHDF family regulated the PEDV replication by affecting the stability of m6A-modified viral RNA. In particular, PEDV infection could trigger an increasement of m6A in host RNA and decrease the expression of FTO. The m6A modification sites in mRNAs and target genes were also altered during PEDV infection. Additionally, part of the host responses to PEDV infection was controlled by m6A modification, which could be reversed by the expression of FTO. Taken together, our results identified the role of m6A modification in PEDV replication and interactions with the host." @default.
• W3036007768 created "2020-06-25" @default.
• W3036007768 creator A5006948080 @default.
• W3036007768 creator A5028635925 @default.
• W3036007768 creator A5042704924 @default.
• W3036007768 creator A5060802166 @default.
• W3036007768 creator A5069302614 @default.
• W3036007768 creator A5069599527 @default.
• W3036007768 creator A5085035359 @default.
• W3036007768 date "2020-09-01" @default.
• W3036007768 modified "2023-09-29" @default.
• W3036007768 title "N6-methyladenosine regulates PEDV replication and host gene expression" @default.
• W3036007768 cites W1130420884 @default.
• W3036007768 cites W1559438287 @default.
• W3036007768 cites W1570484815 @default.
• W3036007768 cites W1584664429 @default.
• W3036007768 cites W1895681508 @default.
• W3036007768 cites W1941339056 @default.
• W3036007768 cites W1978013460 @default.
• W3036007768 cites W1991807334 @default.
• W3036007768 cites W2018101006 @default.
• W3036007768 cites W2022770379 @default.
• W3036007768 cites W2027703044 @default.
• W3036007768 cites W2054101905 @default.
• W3036007768 cites W2064614845 @default.
• W3036007768 cites W2065847836 @default.
• W3036007768 cites W2071930821 @default.
• W3036007768 cites W2085106808 @default.
• W3036007768 cites W2085607662 @default.
• W3036007768 cites W2091235283 @default.
• W3036007768 cites W2091724447 @default.
• W3036007768 cites W2093764457 @default.
• W3036007768 cites W2102872651 @default.
• W3036007768 cites W2106365091 @default.
• W3036007768 cites W2165547003 @default.
• W3036007768 cites W2169203796 @default.
• W3036007768 cites W2169494000 @default.
• W3036007768 cites W2262289299 @default.
• W3036007768 cites W2327216023 @default.
• W3036007768 cites W2336857745 @default.
• W3036007768 cites W2410614396 @default.
• W3036007768 cites W2462449071 @default.
• W3036007768 cites W2465672002 @default.
• W3036007768 cites W2507685096 @default.
• W3036007768 cites W2509465044 @default.
• W3036007768 cites W2532091902 @default.
• W3036007768 cites W2538543247 @default.
• W3036007768 cites W2546967042 @default.
• W3036007768 cites W2578506026 @default.
• W3036007768 cites W2754900935 @default.
• W3036007768 cites W2790194840 @default.
• W3036007768 cites W2791790309 @default.
• W3036007768 cites W2892812430 @default.
• W3036007768 cites W2898209133 @default.
• W3036007768 cites W2909531636 @default.
• W3036007768 cites W2915489297 @default.
• W3036007768 cites W2958498177 @default.
• W3036007768 cites W2969864448 @default.
• W3036007768 doi "https://doi.org/10.1016/j.virol.2020.06.008" @default.
• W3036007768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7297182" @default.
• W3036007768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32838947" @default.
• W3036007768 hasPublicationYear "2020" @default.
• W3036007768 type Work @default.
• W3036007768 sameAs 3036007768 @default.
• W3036007768 citedByCount "21" @default.
• W3036007768 countsByYear W30360077682020 @default.
• W3036007768 countsByYear W30360077682021 @default.
• W3036007768 countsByYear W30360077682022 @default.
• W3036007768 countsByYear W30360077682023 @default.
• W3036007768 crossrefType "journal-article" @default.
• W3036007768 hasAuthorship W3036007768A5006948080 @default.
• W3036007768 hasAuthorship W3036007768A5028635925 @default.
• W3036007768 hasAuthorship W3036007768A5042704924 @default.
• W3036007768 hasAuthorship W3036007768A5060802166 @default.
• W3036007768 hasAuthorship W3036007768A5069302614 @default.
• W3036007768 hasAuthorship W3036007768A5069599527 @default.
• W3036007768 hasAuthorship W3036007768A5085035359 @default.
• W3036007768 hasBestOaLocation W30360077681 @default.
• W3036007768 hasConcept C104317684 @default.
• W3036007768 hasConcept C119056186 @default.
• W3036007768 hasConcept C140704245 @default.
• W3036007768 hasConcept C159047783 @default.
• W3036007768 hasConcept C166703698 @default.
• W3036007768 hasConcept C173396325 @default.
• W3036007768 hasConcept C2191507 @default.
• W3036007768 hasConcept C22615655 @default.
• W3036007768 hasConcept C2522874641 @default.
• W3036007768 hasConcept C2775963939 @default.
• W3036007768 hasConcept C2781364455 @default.
• W3036007768 hasConcept C33288867 @default.
• W3036007768 hasConcept C41091548 @default.
• W3036007768 hasConcept C54355233 @default.
• W3036007768 hasConcept C67705224 @default.
• W3036007768 hasConcept C86803240 @default.
• W3036007768 hasConcept C91965660 @default.
• W3036007768 hasConceptScore W3036007768C104317684 @default.
• W3036007768 hasConceptScore W3036007768C119056186 @default.
• W3036007768 hasConceptScore W3036007768C140704245 @default.

• next