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• W3036008439 endingPage "103909" @default.
• W3036008439 startingPage "103909" @default.
• W3036008439 abstract "Interstitial lung disease (ILD) in children (chILD) is a heterogeneous group of rare respiratory disorders that are mostly chronic and associated with high morbidity and mortality. The pathogenesis of the various chILD is complex and the diseases share common features of inflammatory and fibrotic changes of the lung parenchyma that impair gas exchanges. The etiologies of chILD are numerous. In this review, we chose to classify them as ILD related to exposure/environment insults, ILD related to systemic and immunological diseases, ILD related to primary lung parenchyma dysfunctions and ILD specific to infancy. A growing part of the etiologic spectrum of chILD is being attributed to molecular defects. Currently, the main genetic mutations associated with chILD are identified in the surfactant genes SFTPA1, SFTPA2, SFTPB, SFTPC, ABCA3 and NKX2-1. Other genetic contributors include mutations in MARS, CSF2RA and CSF2RB in pulmonary alveolar proteinosis, and mutations in TMEM173 and COPA in specific auto-inflammatory forms of chILD. However, only few genotype-phenotype correlations could be identified so far. Herein, information is provided about the clinical presentation and the diagnosis approach of chILD. Despite improvements in patient management, the therapeutic strategies are still relying mostly on corticosteroids although specific therapies are emerging. Larger longitudinal cohorts of patients are being gathered through ongoing international collaborations to improve disease knowledge and targeted therapies. Thus, it is expected that children with ILD will be able to reach the adulthood transition in a better condition." @default.
• W3036008439 created "2020-06-25" @default.
• W3036008439 creator A5043499138 @default.
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• W3036008439 creator A5069092037 @default.
• W3036008439 creator A5088818990 @default.
• W3036008439 creator A5089267619 @default.
• W3036008439 date "2020-06-01" @default.
• W3036008439 modified "2023-10-03" @default.
• W3036008439 title "Interstitial lung diseases in children" @default.
• W3036008439 cites W1495464980 @default.
• W3036008439 cites W1505898321 @default.
• W3036008439 cites W1885482581 @default.
• W3036008439 cites W1909432422 @default.
• W3036008439 cites W1915463602 @default.
• W3036008439 cites W1938466749 @default.
• W3036008439 cites W1966408457 @default.
• W3036008439 cites W1967424678 @default.
• W3036008439 cites W1976164518 @default.
• W3036008439 cites W1978678714 @default.
• W3036008439 cites W1981312930 @default.
• W3036008439 cites W1989497499 @default.
• W3036008439 cites W2003464555 @default.
• W3036008439 cites W2015310325 @default.
• W3036008439 cites W2016658685 @default.
• W3036008439 cites W2019094071 @default.
• W3036008439 cites W2019467489 @default.
• W3036008439 cites W2022849704 @default.
• W3036008439 cites W2024589286 @default.
• W3036008439 cites W2031441026 @default.
• W3036008439 cites W2037819900 @default.
• W3036008439 cites W2041607796 @default.
• W3036008439 cites W2045730105 @default.
• W3036008439 cites W2046716130 @default.
• W3036008439 cites W2047488756 @default.
• W3036008439 cites W2052313079 @default.
• W3036008439 cites W2055905830 @default.
• W3036008439 cites W2062456536 @default.
• W3036008439 cites W2063229597 @default.
• W3036008439 cites W2073038315 @default.
• W3036008439 cites W2078288169 @default.
• W3036008439 cites W2078540517 @default.
• W3036008439 cites W2080828667 @default.
• W3036008439 cites W2081758257 @default.
• W3036008439 cites W2086966586 @default.
• W3036008439 cites W2089363206 @default.
• W3036008439 cites W2091776206 @default.
• W3036008439 cites W2094486967 @default.
• W3036008439 cites W2102515649 @default.
• W3036008439 cites W2103580878 @default.
• W3036008439 cites W2103822616 @default.
• W3036008439 cites W2104927376 @default.
• W3036008439 cites W2105295815 @default.
• W3036008439 cites W2112423674 @default.
• W3036008439 cites W2116934677 @default.
• W3036008439 cites W2119545235 @default.
• W3036008439 cites W2120764292 @default.
• W3036008439 cites W2124124986 @default.
• W3036008439 cites W2124578354 @default.
• W3036008439 cites W2125377718 @default.
• W3036008439 cites W2127156531 @default.
• W3036008439 cites W2127494108 @default.
• W3036008439 cites W2127619636 @default.
• W3036008439 cites W2128835497 @default.
• W3036008439 cites W2135349159 @default.
• W3036008439 cites W2135657036 @default.
• W3036008439 cites W2138598430 @default.
• W3036008439 cites W2138871107 @default.
• W3036008439 cites W2139153254 @default.
• W3036008439 cites W2139236274 @default.
• W3036008439 cites W2140713876 @default.
• W3036008439 cites W2142832452 @default.
• W3036008439 cites W2143188326 @default.
• W3036008439 cites W2143750423 @default.
• W3036008439 cites W2149661971 @default.
• W3036008439 cites W2151927487 @default.
• W3036008439 cites W2154136676 @default.
• W3036008439 cites W2154675529 @default.
• W3036008439 cites W2155501613 @default.
• W3036008439 cites W2155809127 @default.
• W3036008439 cites W2155815534 @default.
• W3036008439 cites W2163147529 @default.
• W3036008439 cites W2163471052 @default.
• W3036008439 cites W2167506008 @default.
• W3036008439 cites W2167631658 @default.
• W3036008439 cites W2176818153 @default.
• W3036008439 cites W2178072865 @default.
• W3036008439 cites W2178605123 @default.
• W3036008439 cites W2195285786 @default.
• W3036008439 cites W2238801789 @default.
• W3036008439 cites W2272430157 @default.
• W3036008439 cites W2290881982 @default.
• W3036008439 cites W2310432376 @default.
• W3036008439 cites W2331089332 @default.
• W3036008439 cites W2334646199 @default.
• W3036008439 cites W2335335753 @default.
• W3036008439 cites W2338557222 @default.
• W3036008439 cites W2406574529 @default.

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