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- W3036015800 endingPage "328" @default.
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- W3036015800 abstract "Acinetobacter baumannii is an important nosocomial bacterial pathogen. Multidrug-resistant isolates of A. baumannii are reported worldwide. Some A. baumannii isolates display resistance to nearly all antibiotics, making treatment of infections very challenging. As the need for new and effective antibiotics against A. baumannii becomes increasingly urgent, there is a need to understand the mechanisms of antibiotic resistance and virulence in this organism. In this work, comparative genomics was used to understand the mechanisms of antibiotic resistance and virulence in AB030, an extremely drug-resistant and hypervirulent strain of A. baumannii that is a representative of a recently emerged lineage of A. baumannii International Clone V. In order to characterize AB030, we carried out a genomic and phenotypic comparison with LAC-4, a previously described hyper-resistant and hypervirulent isolate. AB030 contains a number of antibiotic resistance- and virulence-associated genes that are not present in LAC-4. A number of these genes are present on mobile elements. This work shows the importance of characterizing the members of new lineages of A. baumannii in order to determine the development of antibiotic resistance and virulence in this organism." @default.
- W3036015800 created "2020-06-25" @default.
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- W3036015800 date "2020-06-17" @default.
- W3036015800 modified "2023-10-01" @default.
- W3036015800 title "Characterization of Extremely Drug-Resistant and Hypervirulent Acinetobacter baumannii AB030" @default.
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- W3036015800 doi "https://doi.org/10.3390/antibiotics9060328" @default.
- W3036015800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7345994" @default.
- W3036015800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32560407" @default.
- W3036015800 hasPublicationYear "2020" @default.
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