Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036016288> ?p ?o ?g. }
- W3036016288 endingPage "151436" @default.
- W3036016288 startingPage "151436" @default.
- W3036016288 abstract "Staphylococcus aureus is a gram-positive pathogenic bacterium and is capable of secreting numerous toxins interfering directly with the host to cause acute infections. Rbf, a transcriptional regulator of AraC/XylS family, has been reported to promote biofilm formation in polysaccharide intercellular adhesion (PIA) mediated manner to cause chronic infections. In this study, we revealed the new virulence-mediated role of Rbf that can negatively regulate the hemolytic activity. Furthermore, Rbf can specifically bind to the hla and psmα promoters to repress their expression, resulting in significantly decreased production of phenol-soluble modulins α (PSMα) and alpha-toxin. Accordingly, the rbf mutant strain exhibited the increased pathogenicity compared to the wild-type (WT) strain in a mouse subcutaneous abscess model, representing a type of acute infection by S. aureus. Collectively, our results provide a novel insight into the virulence regulation and acute infections mediated by Rbf in S. aureus." @default.
- W3036016288 created "2020-06-25" @default.
- W3036016288 creator A5006539215 @default.
- W3036016288 creator A5020914629 @default.
- W3036016288 creator A5054464905 @default.
- W3036016288 date "2020-07-01" @default.
- W3036016288 modified "2023-09-25" @default.
- W3036016288 title "Transcriptional regulation of virulence factors Hla and phenol-soluble modulins α by AraC-type regulator Rbf in Staphylococcus aureus" @default.
- W3036016288 cites W1593572782 @default.
- W3036016288 cites W1966321620 @default.
- W3036016288 cites W1970783326 @default.
- W3036016288 cites W1974448472 @default.
- W3036016288 cites W1985852848 @default.
- W3036016288 cites W1993944409 @default.
- W3036016288 cites W2000693703 @default.
- W3036016288 cites W2003484929 @default.
- W3036016288 cites W2012061156 @default.
- W3036016288 cites W2030683115 @default.
- W3036016288 cites W2033353380 @default.
- W3036016288 cites W2037541009 @default.
- W3036016288 cites W2037679972 @default.
- W3036016288 cites W2043082319 @default.
- W3036016288 cites W2044062947 @default.
- W3036016288 cites W2044413262 @default.
- W3036016288 cites W2044750677 @default.
- W3036016288 cites W2046708334 @default.
- W3036016288 cites W2050161704 @default.
- W3036016288 cites W2052831663 @default.
- W3036016288 cites W2054899812 @default.
- W3036016288 cites W2058249099 @default.
- W3036016288 cites W2078039265 @default.
- W3036016288 cites W2106092196 @default.
- W3036016288 cites W2108580349 @default.
- W3036016288 cites W2108754827 @default.
- W3036016288 cites W2114987240 @default.
- W3036016288 cites W2118021257 @default.
- W3036016288 cites W2119768770 @default.
- W3036016288 cites W2124693024 @default.
- W3036016288 cites W2126269158 @default.
- W3036016288 cites W2132114933 @default.
- W3036016288 cites W2138914127 @default.
- W3036016288 cites W2146856669 @default.
- W3036016288 cites W2148253865 @default.
- W3036016288 cites W2197568489 @default.
- W3036016288 cites W2314649741 @default.
- W3036016288 cites W2337296334 @default.
- W3036016288 cites W2346909855 @default.
- W3036016288 cites W2419501831 @default.
- W3036016288 cites W2604994651 @default.
- W3036016288 cites W2767637762 @default.
- W3036016288 cites W2773386950 @default.
- W3036016288 cites W2808857036 @default.
- W3036016288 cites W2898505561 @default.
- W3036016288 cites W2913682882 @default.
- W3036016288 cites W4211016618 @default.
- W3036016288 cites W4244678796 @default.
- W3036016288 doi "https://doi.org/10.1016/j.ijmm.2020.151436" @default.
- W3036016288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32654771" @default.
- W3036016288 hasPublicationYear "2020" @default.
- W3036016288 type Work @default.
- W3036016288 sameAs 3036016288 @default.
- W3036016288 citedByCount "8" @default.
- W3036016288 countsByYear W30360162882020 @default.
- W3036016288 countsByYear W30360162882021 @default.
- W3036016288 countsByYear W30360162882022 @default.
- W3036016288 countsByYear W30360162882023 @default.
- W3036016288 crossrefType "journal-article" @default.
- W3036016288 hasAuthorship W3036016288A5006539215 @default.
- W3036016288 hasAuthorship W3036016288A5020914629 @default.
- W3036016288 hasAuthorship W3036016288A5054464905 @default.
- W3036016288 hasBestOaLocation W30360162881 @default.
- W3036016288 hasConcept C104317684 @default.
- W3036016288 hasConcept C143065580 @default.
- W3036016288 hasConcept C2779489039 @default.
- W3036016288 hasConcept C2781090273 @default.
- W3036016288 hasConcept C523546767 @default.
- W3036016288 hasConcept C54355233 @default.
- W3036016288 hasConcept C58123911 @default.
- W3036016288 hasConcept C60987743 @default.
- W3036016288 hasConcept C86803240 @default.
- W3036016288 hasConcept C89423630 @default.
- W3036016288 hasConceptScore W3036016288C104317684 @default.
- W3036016288 hasConceptScore W3036016288C143065580 @default.
- W3036016288 hasConceptScore W3036016288C2779489039 @default.
- W3036016288 hasConceptScore W3036016288C2781090273 @default.
- W3036016288 hasConceptScore W3036016288C523546767 @default.
- W3036016288 hasConceptScore W3036016288C54355233 @default.
- W3036016288 hasConceptScore W3036016288C58123911 @default.
- W3036016288 hasConceptScore W3036016288C60987743 @default.
- W3036016288 hasConceptScore W3036016288C86803240 @default.
- W3036016288 hasConceptScore W3036016288C89423630 @default.
- W3036016288 hasFunder F4320321001 @default.
- W3036016288 hasIssue "5" @default.
- W3036016288 hasLocation W30360162881 @default.
- W3036016288 hasLocation W30360162882 @default.
- W3036016288 hasOpenAccess W3036016288 @default.
- W3036016288 hasPrimaryLocation W30360162881 @default.
- W3036016288 hasRelatedWork W1977571916 @default.