FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036019058> ?p ?o ?g. }

• W3036019058 endingPage "4368" @default.
• W3036019058 startingPage "4368" @default.
• W3036019058 abstract "Bacterial infection of biomaterials is a serious problem in the field of medical devices. It is urgently necessary to develop new biomaterials with bactericidal activity. Antimicrobial peptides and proteins (AMPs), alternative antibacterial agents, are expected to overcome the bacterial resistance. The aim of this study was to develop a new intelligent material in bone tissue engineering based on protamine-loaded hydroxyapatite (protamine/HAp) that uses AMPs rather than antibiotics. It was found that the adsorption of protamine to HAp followed the Langmuir adsorption model and was due to electrostatic and/or hydrophobic interactions. In vitro bacterial adhesion and growth on protamine/HAp was inhibited in a protamine dose-dependent manner. Adherent bacteria exhibited an aberrant morphology for high dosages of protamine/HAp, resulting in the formation of large aggregates and disintegration of the membrane. The released protamine from protamine/HAp also prevented the growth of planktonic bacteria in vitro. However, a high dosage of protamine from powders at loading concentrations over 1000 μg·mL−1 induced a cytotoxic effect in vitro, although those exhibited no apparent cytotoxicity in vivo. These data revealed that protamine/HAp (less than 1000 μg·mL−1) had both antimicrobial activity and biocompatibility and can be applied for bone substitutes in orthopedic fields." @default.
• W3036019058 created "2020-06-25" @default.
• W3036019058 creator A5035116488 @default.
• W3036019058 creator A5050562947 @default.
• W3036019058 creator A5081034610 @default.
• W3036019058 date "2020-06-19" @default.
• W3036019058 modified "2023-10-16" @default.
• W3036019058 title "Potential Application of Protamine for Antimicrobial Biomaterials in Bone Tissue Engineering" @default.
• W3036019058 cites W1531846676 @default.
• W3036019058 cites W1567150406 @default.
• W3036019058 cites W1597755781 @default.
• W3036019058 cites W1957092924 @default.
• W3036019058 cites W1963878748 @default.
• W3036019058 cites W1975564816 @default.
• W3036019058 cites W1979973356 @default.
• W3036019058 cites W1989734247 @default.
• W3036019058 cites W1989998611 @default.
• W3036019058 cites W1993864236 @default.
• W3036019058 cites W2022998979 @default.
• W3036019058 cites W2028029982 @default.
• W3036019058 cites W2048414834 @default.
• W3036019058 cites W2058919317 @default.
• W3036019058 cites W2063261010 @default.
• W3036019058 cites W2064837586 @default.
• W3036019058 cites W2064888995 @default.
• W3036019058 cites W2068174333 @default.
• W3036019058 cites W2111204347 @default.
• W3036019058 cites W2155622354 @default.
• W3036019058 cites W2167839343 @default.
• W3036019058 cites W2402758384 @default.
• W3036019058 cites W2522332139 @default.
• W3036019058 cites W2787483916 @default.
• W3036019058 cites W2791979498 @default.
• W3036019058 cites W2944234091 @default.
• W3036019058 cites W2971151499 @default.
• W3036019058 cites W2985733372 @default.
• W3036019058 cites W4235106149 @default.
• W3036019058 cites W4245397175 @default.
• W3036019058 doi "https://doi.org/10.3390/ijms21124368" @default.
• W3036019058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7352774" @default.
• W3036019058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32575446" @default.
• W3036019058 hasPublicationYear "2020" @default.
• W3036019058 type Work @default.
• W3036019058 sameAs 3036019058 @default.
• W3036019058 citedByCount "14" @default.
• W3036019058 countsByYear W30360190582021 @default.
• W3036019058 countsByYear W30360190582022 @default.
• W3036019058 countsByYear W30360190582023 @default.
• W3036019058 crossrefType "journal-article" @default.
• W3036019058 hasAuthorship W3036019058A5035116488 @default.
• W3036019058 hasAuthorship W3036019058A5050562947 @default.
• W3036019058 hasAuthorship W3036019058A5081034610 @default.
• W3036019058 hasBestOaLocation W30360190581 @default.
• W3036019058 hasConcept C109316439 @default.
• W3036019058 hasConcept C150903083 @default.
• W3036019058 hasConcept C178790620 @default.
• W3036019058 hasConcept C185592680 @default.
• W3036019058 hasConcept C202751555 @default.
• W3036019058 hasConcept C207001950 @default.
• W3036019058 hasConcept C2777230088 @default.
• W3036019058 hasConcept C2777557582 @default.
• W3036019058 hasConcept C2780835560 @default.
• W3036019058 hasConcept C4937899 @default.
• W3036019058 hasConcept C501593827 @default.
• W3036019058 hasConcept C540938839 @default.
• W3036019058 hasConcept C55493867 @default.
• W3036019058 hasConcept C86803240 @default.
• W3036019058 hasConcept C89423630 @default.
• W3036019058 hasConcept C98274493 @default.
• W3036019058 hasConceptScore W3036019058C109316439 @default.
• W3036019058 hasConceptScore W3036019058C150903083 @default.
• W3036019058 hasConceptScore W3036019058C178790620 @default.
• W3036019058 hasConceptScore W3036019058C185592680 @default.
• W3036019058 hasConceptScore W3036019058C202751555 @default.
• W3036019058 hasConceptScore W3036019058C207001950 @default.
• W3036019058 hasConceptScore W3036019058C2777230088 @default.
• W3036019058 hasConceptScore W3036019058C2777557582 @default.
• W3036019058 hasConceptScore W3036019058C2780835560 @default.
• W3036019058 hasConceptScore W3036019058C4937899 @default.
• W3036019058 hasConceptScore W3036019058C501593827 @default.
• W3036019058 hasConceptScore W3036019058C540938839 @default.
• W3036019058 hasConceptScore W3036019058C55493867 @default.
• W3036019058 hasConceptScore W3036019058C86803240 @default.
• W3036019058 hasConceptScore W3036019058C89423630 @default.
• W3036019058 hasConceptScore W3036019058C98274493 @default.
• W3036019058 hasFunder F4320322310 @default.
• W3036019058 hasIssue "12" @default.
• W3036019058 hasLocation W30360190581 @default.
• W3036019058 hasLocation W30360190582 @default.
• W3036019058 hasLocation W30360190583 @default.
• W3036019058 hasOpenAccess W3036019058 @default.
• W3036019058 hasPrimaryLocation W30360190581 @default.
• W3036019058 hasRelatedWork W1592261125 @default.
• W3036019058 hasRelatedWork W1981376286 @default.
• W3036019058 hasRelatedWork W1982027601 @default.
• W3036019058 hasRelatedWork W1986841751 @default.
• W3036019058 hasRelatedWork W2076847811 @default.
• W3036019058 hasRelatedWork W2416964709 @default.

• next