FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036060770> ?p ?o ?g. }

• W3036060770 endingPage "926" @default.
• W3036060770 startingPage "926" @default.
• W3036060770 abstract "Alterations of adipose tissue occurring in obesity have been recognized as a major risk factor for several cancers. The relationship between adipose tissue and lung cancer, which is the main cancer-related cause of death worldwide, still requires investigation. Perturbations in the adipokine system are likely to interfere with inter-organ crosstalk in lung cancer, which may influence the lung tumor microenvironment. Adiponectin (Acrp30) expression is deregulated in several cancer types. Acrp30 circulates as oligomers with a Low (LMW), Medium (MMW), and High Molecular Weight (HMW), with the latter mediating the main biological effects. Acrp30 acts through AdipoR1 and AdipoR2 receptors. T-cadherin has been described as a non-signaling receptor. This study’s aim was to investigate the regulation of serum Acrp30 and its receptors in sample tissue from non-small cell lung cancer (NSCLC) patients. We recruited 72 NSCLC patients and 60 healthy controls, whom we evaluated in terms of their Acpr30 levels and oligomeric profile. In addition, the expression of AdipoRs in tissues from lung cancer specimens was also measured and compared to coupled healthy lung samples. Our findings show a significant reduction of total Acrp30 levels in NSCLC patients compared to normal subjects, with a specific down-regulation of HMW oligomers. Acrp30 expression was lower in lung adenocarcinoma than other subtypes, regardless of other factors. A significantly higher expression of AdipoR1 was observed, while no differences in R2 and a lower expression of T-cadherin were found in lung cancer specimens compared to normal healthy lung tissues. Involvement of the Acrp30 system in lung cancer may provide new insight into the interaction between adipose tissue and lung and sheds light on its potential ability to influence the lung tumor microenvironment." @default.
• W3036060770 created "2020-06-25" @default.
• W3036060770 creator A5028834608 @default.
• W3036060770 creator A5034936890 @default.
• W3036060770 creator A5048773551 @default.
• W3036060770 creator A5054387553 @default.
• W3036060770 creator A5062907116 @default.
• W3036060770 creator A5073420952 @default.
• W3036060770 creator A5074560480 @default.
• W3036060770 creator A5076467327 @default.
• W3036060770 date "2020-06-18" @default.
• W3036060770 modified "2023-10-05" @default.
• W3036060770 title "Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study" @default.
• W3036060770 cites W1530658269 @default.
• W3036060770 cites W1971452427 @default.
• W3036060770 cites W1986697703 @default.
• W3036060770 cites W1991816874 @default.
• W3036060770 cites W2009681741 @default.
• W3036060770 cites W2024481006 @default.
• W3036060770 cites W2035083604 @default.
• W3036060770 cites W2043580174 @default.
• W3036060770 cites W2055843695 @default.
• W3036060770 cites W2069867624 @default.
• W3036060770 cites W2078064252 @default.
• W3036060770 cites W2079801856 @default.
• W3036060770 cites W2107769418 @default.
• W3036060770 cites W2125970092 @default.
• W3036060770 cites W2128307821 @default.
• W3036060770 cites W2163886829 @default.
• W3036060770 cites W2316700556 @default.
• W3036060770 cites W2333384502 @default.
• W3036060770 cites W2466059757 @default.
• W3036060770 cites W2563791715 @default.
• W3036060770 cites W2578346201 @default.
• W3036060770 cites W2604281603 @default.
• W3036060770 cites W2612043088 @default.
• W3036060770 cites W2612427157 @default.
• W3036060770 cites W2741592245 @default.
• W3036060770 cites W2768439293 @default.
• W3036060770 cites W2789550512 @default.
• W3036060770 cites W2796192631 @default.
• W3036060770 cites W2801755815 @default.
• W3036060770 cites W2895752892 @default.
• W3036060770 cites W2909680436 @default.
• W3036060770 cites W2910728038 @default.
• W3036060770 cites W2914157248 @default.
• W3036060770 cites W2917679119 @default.
• W3036060770 cites W2947780266 @default.
• W3036060770 cites W2950772595 @default.
• W3036060770 cites W2968373163 @default.
• W3036060770 cites W2970662676 @default.
• W3036060770 cites W2977498640 @default.
• W3036060770 cites W2977690259 @default.
• W3036060770 cites W2979773890 @default.
• W3036060770 cites W2981876540 @default.
• W3036060770 cites W2984981484 @default.
• W3036060770 cites W2986569415 @default.
• W3036060770 cites W2997939984 @default.
• W3036060770 cites W3008990034 @default.
• W3036060770 doi "https://doi.org/10.3390/biom10060926" @default.
• W3036060770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7356727" @default.
• W3036060770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32570854" @default.
• W3036060770 hasPublicationYear "2020" @default.
• W3036060770 type Work @default.
• W3036060770 sameAs 3036060770 @default.
• W3036060770 citedByCount "13" @default.
• W3036060770 countsByYear W30360607702020 @default.
• W3036060770 countsByYear W30360607702021 @default.
• W3036060770 countsByYear W30360607702022 @default.
• W3036060770 countsByYear W30360607702023 @default.
• W3036060770 crossrefType "journal-article" @default.
• W3036060770 hasAuthorship W3036060770A5028834608 @default.
• W3036060770 hasAuthorship W3036060770A5034936890 @default.
• W3036060770 hasAuthorship W3036060770A5048773551 @default.
• W3036060770 hasAuthorship W3036060770A5054387553 @default.
• W3036060770 hasAuthorship W3036060770A5062907116 @default.
• W3036060770 hasAuthorship W3036060770A5073420952 @default.
• W3036060770 hasAuthorship W3036060770A5074560480 @default.
• W3036060770 hasAuthorship W3036060770A5076467327 @default.
• W3036060770 hasBestOaLocation W30360607701 @default.
• W3036060770 hasConcept C121608353 @default.
• W3036060770 hasConcept C126322002 @default.
• W3036060770 hasConcept C143998085 @default.
• W3036060770 hasConcept C170493617 @default.
• W3036060770 hasConcept C171089720 @default.
• W3036060770 hasConcept C194832188 @default.
• W3036060770 hasConcept C2776256026 @default.
• W3036060770 hasConcept C2776782570 @default.
• W3036060770 hasConcept C2777391703 @default.
• W3036060770 hasConcept C2777714996 @default.
• W3036060770 hasConcept C2780613262 @default.
• W3036060770 hasConcept C2781182431 @default.
• W3036060770 hasConcept C502942594 @default.
• W3036060770 hasConcept C511355011 @default.
• W3036060770 hasConcept C71924100 @default.
• W3036060770 hasConcept C86803240 @default.
• W3036060770 hasConceptScore W3036060770C121608353 @default.
• W3036060770 hasConceptScore W3036060770C126322002 @default.

• next