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- W3036072414 abstract "Diabetogenic agents can be conveniently classified into simple chemicals and complex hormones. Streptozotocin and alloxan are diabetogenic chemicals which cause a permanent diabetes by destruction of the B cells of the islets of Langerhans of the pancreas and a resulting insulin deficiency. The diabetogenic chemicals, however, may also have sex hormone-like actions which could be contributory or even causative factors in diabetes mellitus. Circulating androgens have long been known to effect a sexual dimorphism of the submandibular gland,and spontaneous diabetes markedly affects the development of the submandibular glands of mice. The effects of alloxan on the submandibular gland of male mice has previously been reported. In the present study, the effects of streptozotocin, a diabetogenic agent widely employed in cancer chemotherapy, were investigated in heterozygous male mice of the C57BI, Ksj db strain whose homozygous littermates are afflicted with a syndrome resembling maturity-onset human diabetes mellitus." @default.
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- W3036072414 date "1981-08-01" @default.
- W3036072414 modified "2023-09-24" @default.
- W3036072414 title "Effects of Streptozotocin and Alloxan on Granular Tubules of Male Mouse Submandibular Gland" @default.
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- W3036072414 doi "https://doi.org/10.1017/s0424820100099404" @default.
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