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- W3036103654 abstract "A fundamentally new understanding of cardiac excitation-contraction (E-C) coupling is being developed from recent experimental work using confocal microscopy of single isolated heart cells. In particular, the transient change in intracellular free calcium ion concentration ([Ca 2+ ] i transient) that activates muscle contraction is now viewed as resulting from the spatial and temporal summation of small (∼ 8 μm 3 ), subcellular, stereotyped ‘local [Ca 2+ ] i -transients' or, as they have been called, ‘calcium sparks'. This new understanding may be called ‘local control of E-C coupling'. The relevance to normal heart cell function of ‘local control, theory and the recent confocal data on spontaneous Ca 2+ ‘sparks', and on electrically evoked local [Ca 2+ ] i -transients has been unknown however, because the previous studies were all conducted on slack, internally perfused, single, enzymatically dissociated cardiac cells, at room temperature, usually with Cs + replacing K + , and often in the presence of Ca 2 -channel blockers. The present work was undertaken to establish whether or not the concepts derived from these studies are in fact relevant to normal cardiac tissue under physiological conditions, by attempting to record local [Ca 2+ ] i -transients, sparks (and Ca 2+ waves) in intact, multi-cellular cardiac tissue." @default.
- W3036103654 created "2020-06-25" @default.
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- W3036103654 date "1996-08-11" @default.
- W3036103654 modified "2023-09-26" @default.
- W3036103654 title "Confocal imaging of calcium in intact ventricular muscle provides a new view of excitation-contraction coupling" @default.
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- W3036103654 doi "https://doi.org/10.1017/s0424820100166154" @default.
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