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- W3036106746 abstract "Abstract Midbrain dopaminergic (DA) axons make long longitudinal projections towards the striatum. Despite the importance of DA striatal innervation, processes involved in establishment of DA axonal connectivity remain largely unknown. Here we demonstrate a striatal-specific requirement of transcriptional regulator Nolz1 in establishing DA circuitry formation. DA projections are misguided and fail to innervate the striatum in both constitutive and striatal-specific Nolz1 mutant embryos. The lack of striatal Nolz1 expression results in nigral to pallidal lineage conversion of striatal projection neuron subtypes. This lineage switch alters the composition of secreted factors influencing DA axonal tract formation and renders the striatum non-permissive for dopaminergic and other forebrain tracts. Furthermore, transcriptomic analysis of wild-type and Nolz1 −/− mutant striatal tissue led to the identification of several secreted factors that underlie the observed guidance defects and proteins that promote DA axonal outgrowth. Together, our data demonstrate the involvement of the striatum in orchestrating dopaminergic circuitry formation." @default.
- W3036106746 created "2020-06-25" @default.
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- W3036106746 date "2020-06-19" @default.
- W3036106746 modified "2023-09-28" @default.
- W3036106746 title "Nolz1 expression is required in dopaminergic axon guidance and striatal innervation" @default.
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- W3036106746 cites W1843290366 @default.
- W3036106746 cites W1913309343 @default.
- W3036106746 cites W1944889304 @default.
- W3036106746 cites W1966343623 @default.
- W3036106746 cites W1966843273 @default.
- W3036106746 cites W1969276438 @default.
- W3036106746 cites W1975811251 @default.
- W3036106746 cites W1981978912 @default.
- W3036106746 cites W1983216462 @default.
- W3036106746 cites W1984371783 @default.
- W3036106746 cites W1987180132 @default.
- W3036106746 cites W1993634104 @default.
- W3036106746 cites W1999998616 @default.
- W3036106746 cites W2014363859 @default.
- W3036106746 cites W2014479208 @default.
- W3036106746 cites W2014651004 @default.
- W3036106746 cites W2020725045 @default.
- W3036106746 cites W2021017423 @default.
- W3036106746 cites W2026001265 @default.
- W3036106746 cites W2030416616 @default.
- W3036106746 cites W2031819075 @default.
- W3036106746 cites W2042528026 @default.
- W3036106746 cites W2052480977 @default.
- W3036106746 cites W2056789333 @default.
- W3036106746 cites W2063965661 @default.
- W3036106746 cites W2064521170 @default.
- W3036106746 cites W2064908322 @default.
- W3036106746 cites W2068119597 @default.
- W3036106746 cites W2068391384 @default.
- W3036106746 cites W2069582700 @default.
- W3036106746 cites W2076499613 @default.
- W3036106746 cites W2080124031 @default.
- W3036106746 cites W2081021881 @default.
- W3036106746 cites W2085461877 @default.
- W3036106746 cites W2085915238 @default.
- W3036106746 cites W2103099331 @default.
- W3036106746 cites W2107736130 @default.
- W3036106746 cites W2109410863 @default.
- W3036106746 cites W2114139156 @default.
- W3036106746 cites W2119841530 @default.
- W3036106746 cites W2126544839 @default.
- W3036106746 cites W2140243852 @default.
- W3036106746 cites W2147289229 @default.
- W3036106746 cites W2148908926 @default.
- W3036106746 cites W2150626351 @default.
- W3036106746 cites W2151237279 @default.
- W3036106746 cites W2158018613 @default.
- W3036106746 cites W2162331017 @default.
- W3036106746 cites W2163371631 @default.
- W3036106746 cites W2166046695 @default.
- W3036106746 cites W2166684121 @default.
- W3036106746 cites W2172706654 @default.
- W3036106746 cites W2175605375 @default.
- W3036106746 cites W2287420551 @default.
- W3036106746 cites W2335569705 @default.
- W3036106746 cites W2347201954 @default.
- W3036106746 cites W2413152458 @default.
- W3036106746 cites W2417186252 @default.
- W3036106746 cites W2552101027 @default.
- W3036106746 cites W2588681049 @default.
- W3036106746 cites W2761280295 @default.
- W3036106746 cites W2799652277 @default.
- W3036106746 cites W2804526247 @default.
- W3036106746 cites W2809748547 @default.
- W3036106746 cites W2883748755 @default.
- W3036106746 cites W2883948097 @default.
- W3036106746 cites W2887114149 @default.
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- W3036106746 doi "https://doi.org/10.1038/s41467-020-16947-6" @default.
- W3036106746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7305235" @default.
- W3036106746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32561725" @default.
- W3036106746 hasPublicationYear "2020" @default.
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