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• W3036111502 abstract "Abstract Purpose of Review Fibroblasts, the major cell population in all connective tissues, are best known for their role in depositing and maintaining the extracellular matrix. Recently, numerous specialised functions have been discovered revealing unpredicted fibroblast heterogeneity. We will discuss this heterogeneity, from its origins in development to alterations in fibrotic disease conditions. Recent Findings Advances in lineage tracing and single-cell transcriptional profiling techniques have revealed impressive diversity amongst fibroblasts in a range of organ systems including the skin, lung, kidney and heart. However, there are major challenges in assimilating the findings and understanding their functional significance. Certain fibroblast subsets can make specific contributions to healthy tissue functioning and to fibrotic disease processes; thus, therapeutic manipulation of particular subsets could be clinically beneficial. Summary Here we propose that four key variables determine a fibroblast’s phenotype underpinning their enormous heterogeneity: tissue status, regional features, microenvironment and cell state. We review these in different organ systems, highlighting the importance of understanding the divergent fibroblast properties and underlying mechanisms in tissue fibrosis." @default.
• W3036111502 created "2020-06-25" @default.
• W3036111502 creator A5041476327 @default.
• W3036111502 creator A5066408267 @default.
• W3036111502 date "2020-06-19" @default.
• W3036111502 modified "2023-10-12" @default.
• W3036111502 title "Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease" @default.
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• W3036111502 doi "https://doi.org/10.1007/s11926-020-00903-w" @default.
• W3036111502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7305072" @default.
• W3036111502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32562113" @default.
• W3036111502 hasPublicationYear "2020" @default.
• W3036111502 type Work @default.
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• W3036111502 hasAuthorship W3036111502A5041476327 @default.
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