Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036140229> ?p ?o ?g. }
- W3036140229 endingPage "108452" @default.
- W3036140229 startingPage "108452" @default.
- W3036140229 abstract "Activated hepatic stellate cells (HSCs) are primarily responsible for the accumulation of extracellular matrix substances during the development of liver fibrosis. It has been shown that n-3 polyunsaturated fatty acids (PUFAs) can prevent liver fibrosis development. However, the underlying mechanisms of action need further investigation. The objective of this study was to determine the regulatory roles of fatty acids (FAs) on the expression of profibrogenic genes in HSCs with the elucidation of mechanisms. LX-2 cells and primary human and mouse HSCs were treated with palmitic acid, oleic acid, linoleic acid, α-linolenic acid, eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) to determine their effect on profibrogenic gene expression upon the activation by transforming growth factor β1 (TGFβ1). PUFAs significantly suppressed TGFβ1-induced expression of profibrogenic genes in LX-2 and primary human HSCs with n-3 being more potent than n-6 PUFAs. However, PUFAs did not inhibit the phosphorylation and nuclear translocation of SMA- and MAD-related protein in primary human HSCs. Furthermore, PUFAs did not alter the profibrogenic gene expression in primary mouse HSCs. The inhibitory effect of EPA and DHA on TGFβ1-induced profibrogenic gene expression was diminished by peroxisome proliferator-activated receptor gamma (PPARG) knockdown, although chemical inhibition of PPARγ did not elicit a similar result. The results suggest that n-3 PUFAs possess the most potent protective effects against TGFβ1-induced profibrogenic gene expression, which is, at least in part, PPARγ-dependent in HSCs." @default.
- W3036140229 created "2020-06-25" @default.
- W3036140229 creator A5002218759 @default.
- W3036140229 creator A5011967545 @default.
- W3036140229 creator A5080891156 @default.
- W3036140229 creator A5084009935 @default.
- W3036140229 date "2020-11-01" @default.
- W3036140229 modified "2023-10-17" @default.
- W3036140229 title "n-3 PUFAs inhibit TGFβ1-induced profibrogenic gene expression by ameliorating the repression of PPARγ in hepatic stellate cells" @default.
- W3036140229 cites W1906235443 @default.
- W3036140229 cites W1965149282 @default.
- W3036140229 cites W1966975625 @default.
- W3036140229 cites W1976777085 @default.
- W3036140229 cites W1988587821 @default.
- W3036140229 cites W1989363848 @default.
- W3036140229 cites W1991552651 @default.
- W3036140229 cites W2002276672 @default.
- W3036140229 cites W2008296807 @default.
- W3036140229 cites W2023952437 @default.
- W3036140229 cites W2025484695 @default.
- W3036140229 cites W2025657436 @default.
- W3036140229 cites W2032069060 @default.
- W3036140229 cites W2038408489 @default.
- W3036140229 cites W2056213387 @default.
- W3036140229 cites W2066062196 @default.
- W3036140229 cites W2072721395 @default.
- W3036140229 cites W2072762682 @default.
- W3036140229 cites W2073619483 @default.
- W3036140229 cites W2073878918 @default.
- W3036140229 cites W2078424139 @default.
- W3036140229 cites W2086815118 @default.
- W3036140229 cites W2089149502 @default.
- W3036140229 cites W2089687829 @default.
- W3036140229 cites W2093308509 @default.
- W3036140229 cites W2093824918 @default.
- W3036140229 cites W2096417404 @default.
- W3036140229 cites W2100711329 @default.
- W3036140229 cites W2102298863 @default.
- W3036140229 cites W2102663269 @default.
- W3036140229 cites W2104193042 @default.
- W3036140229 cites W2111288662 @default.
- W3036140229 cites W2118881723 @default.
- W3036140229 cites W2130088396 @default.
- W3036140229 cites W2131891237 @default.
- W3036140229 cites W2141314779 @default.
- W3036140229 cites W2143143193 @default.
- W3036140229 cites W2168393105 @default.
- W3036140229 cites W2204688218 @default.
- W3036140229 cites W2256103742 @default.
- W3036140229 cites W2272657653 @default.
- W3036140229 cites W2291173445 @default.
- W3036140229 cites W2409342108 @default.
- W3036140229 cites W2503056681 @default.
- W3036140229 cites W2530486081 @default.
- W3036140229 cites W2556449831 @default.
- W3036140229 cites W2579251610 @default.
- W3036140229 cites W2596317107 @default.
- W3036140229 cites W2615304118 @default.
- W3036140229 cites W2754370480 @default.
- W3036140229 cites W2756664690 @default.
- W3036140229 cites W2770646078 @default.
- W3036140229 cites W2790389078 @default.
- W3036140229 cites W2937475407 @default.
- W3036140229 cites W2949184819 @default.
- W3036140229 doi "https://doi.org/10.1016/j.jnutbio.2020.108452" @default.
- W3036140229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32745880" @default.
- W3036140229 hasPublicationYear "2020" @default.
- W3036140229 type Work @default.
- W3036140229 sameAs 3036140229 @default.
- W3036140229 citedByCount "10" @default.
- W3036140229 countsByYear W30361402292021 @default.
- W3036140229 countsByYear W30361402292022 @default.
- W3036140229 countsByYear W30361402292023 @default.
- W3036140229 crossrefType "journal-article" @default.
- W3036140229 hasAuthorship W3036140229A5002218759 @default.
- W3036140229 hasAuthorship W3036140229A5011967545 @default.
- W3036140229 hasAuthorship W3036140229A5080891156 @default.
- W3036140229 hasAuthorship W3036140229A5084009935 @default.
- W3036140229 hasBestOaLocation W30361402291 @default.
- W3036140229 hasConcept C118131993 @default.
- W3036140229 hasConcept C134018914 @default.
- W3036140229 hasConcept C153911025 @default.
- W3036140229 hasConcept C170493617 @default.
- W3036140229 hasConcept C176891718 @default.
- W3036140229 hasConcept C187345961 @default.
- W3036140229 hasConcept C19038510 @default.
- W3036140229 hasConcept C2776091944 @default.
- W3036140229 hasConcept C2777171753 @default.
- W3036140229 hasConcept C502942594 @default.
- W3036140229 hasConcept C543025807 @default.
- W3036140229 hasConcept C55493867 @default.
- W3036140229 hasConcept C86803240 @default.
- W3036140229 hasConcept C95444343 @default.
- W3036140229 hasConceptScore W3036140229C118131993 @default.
- W3036140229 hasConceptScore W3036140229C134018914 @default.
- W3036140229 hasConceptScore W3036140229C153911025 @default.
- W3036140229 hasConceptScore W3036140229C170493617 @default.
- W3036140229 hasConceptScore W3036140229C176891718 @default.