Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036162149> ?p ?o ?g. }
- W3036162149 abstract "Abstract Asthma is characterized by pathological airway remodeling resulting from persistent myofibroblast activation. Although transforming growth factor beta 1 (TGFβ1), mechanical signals, and reactive oxygen species (ROS) are implicated in fibroblast differentiation, their integration is still elusive. We identified that Transient Receptor Potential Vanilloid 4 (TRPV4), a mechanosensitive ion channel mediates lung fibroblast (LF) differentiation and D. farinae -induced airway remodeling via a novel TRPV4-NADPH Oxidase 4 (NOX4) interaction. NOX4-mediated ROS production is essential for TGFβ1-induced LF differentiation via myocardin-related transcription factor-A (MRTF-A) and plasminogen activator inhibitor 1 (PAI-1). Importantly, TRPV4 inhibition prevented TGFβ1-induced NOX4 expression and ROS production. Both TRPV4 and NOX4 are activated by phosphatidylinositol 3-kinase (PI3K) downstream of TGFβ1, and signals from both TRPV4 and Rac are necessary for NOX4 upregulation. Notably, NOX4 expression is higher in fibroblasts derived from asthmatic patients (disease human LF; DHLF) in comparison to non-asthmatics (normal human LF; NHLF). Further, NOX4 expression is up-regulated in the lungs of D.farinae -treated wild type mice (WT) relative to saline-treated WT, which was attenuated in TRPV4 knockout (KO) mice. Our findings suggest that TRPV4 integrates TGFβ1 and ROS signaling through NOX4 and, TRPV4-NOX4 interaction is amenable to target lung remodeling during asthma." @default.
- W3036162149 created "2020-06-25" @default.
- W3036162149 creator A5003678570 @default.
- W3036162149 creator A5006238724 @default.
- W3036162149 creator A5013715345 @default.
- W3036162149 creator A5025225086 @default.
- W3036162149 creator A5028517820 @default.
- W3036162149 creator A5033490080 @default.
- W3036162149 creator A5036325104 @default.
- W3036162149 creator A5041770357 @default.
- W3036162149 creator A5067455390 @default.
- W3036162149 creator A5073596245 @default.
- W3036162149 date "2020-06-17" @default.
- W3036162149 modified "2023-10-16" @default.
- W3036162149 title "Transient Receptor Potential Vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH Oxidase 4" @default.
- W3036162149 cites W1505584712 @default.
- W3036162149 cites W150589858 @default.
- W3036162149 cites W1530462678 @default.
- W3036162149 cites W1588127651 @default.
- W3036162149 cites W1922287625 @default.
- W3036162149 cites W1966672647 @default.
- W3036162149 cites W1969154550 @default.
- W3036162149 cites W1975318062 @default.
- W3036162149 cites W1975696541 @default.
- W3036162149 cites W1987492687 @default.
- W3036162149 cites W1991246311 @default.
- W3036162149 cites W1991991967 @default.
- W3036162149 cites W1992534568 @default.
- W3036162149 cites W1994233268 @default.
- W3036162149 cites W1996193998 @default.
- W3036162149 cites W1998329843 @default.
- W3036162149 cites W2004107033 @default.
- W3036162149 cites W2010909603 @default.
- W3036162149 cites W2011977636 @default.
- W3036162149 cites W2013537969 @default.
- W3036162149 cites W2023966975 @default.
- W3036162149 cites W2025644518 @default.
- W3036162149 cites W2030094330 @default.
- W3036162149 cites W2042537814 @default.
- W3036162149 cites W2045142779 @default.
- W3036162149 cites W2046661997 @default.
- W3036162149 cites W2071494920 @default.
- W3036162149 cites W2079666008 @default.
- W3036162149 cites W2081415617 @default.
- W3036162149 cites W2085991478 @default.
- W3036162149 cites W2086319262 @default.
- W3036162149 cites W2087467372 @default.
- W3036162149 cites W2093726551 @default.
- W3036162149 cites W2097466236 @default.
- W3036162149 cites W2117691369 @default.
- W3036162149 cites W2118676765 @default.
- W3036162149 cites W2129236688 @default.
- W3036162149 cites W2131758520 @default.
- W3036162149 cites W2136619497 @default.
- W3036162149 cites W2149429155 @default.
- W3036162149 cites W2156865492 @default.
- W3036162149 cites W2162407632 @default.
- W3036162149 cites W2165179802 @default.
- W3036162149 cites W2166566487 @default.
- W3036162149 cites W2328540437 @default.
- W3036162149 cites W2518884641 @default.
- W3036162149 cites W2531849163 @default.
- W3036162149 cites W2571298844 @default.
- W3036162149 cites W2765195981 @default.
- W3036162149 cites W2945193235 @default.
- W3036162149 doi "https://doi.org/10.1038/s41598-020-66617-2" @default.
- W3036162149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7299963" @default.
- W3036162149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32555397" @default.
- W3036162149 hasPublicationYear "2020" @default.
- W3036162149 type Work @default.
- W3036162149 sameAs 3036162149 @default.
- W3036162149 citedByCount "12" @default.
- W3036162149 countsByYear W30361621492020 @default.
- W3036162149 countsByYear W30361621492021 @default.
- W3036162149 countsByYear W30361621492022 @default.
- W3036162149 countsByYear W30361621492023 @default.
- W3036162149 crossrefType "journal-article" @default.
- W3036162149 hasAuthorship W3036162149A5003678570 @default.
- W3036162149 hasAuthorship W3036162149A5006238724 @default.
- W3036162149 hasAuthorship W3036162149A5013715345 @default.
- W3036162149 hasAuthorship W3036162149A5025225086 @default.
- W3036162149 hasAuthorship W3036162149A5028517820 @default.
- W3036162149 hasAuthorship W3036162149A5033490080 @default.
- W3036162149 hasAuthorship W3036162149A5036325104 @default.
- W3036162149 hasAuthorship W3036162149A5041770357 @default.
- W3036162149 hasAuthorship W3036162149A5067455390 @default.
- W3036162149 hasAuthorship W3036162149A5073596245 @default.
- W3036162149 hasBestOaLocation W30361621491 @default.
- W3036162149 hasConcept C126322002 @default.
- W3036162149 hasConcept C155164980 @default.
- W3036162149 hasConcept C170493617 @default.
- W3036162149 hasConcept C185592680 @default.
- W3036162149 hasConcept C207865475 @default.
- W3036162149 hasConcept C2776061955 @default.
- W3036162149 hasConcept C2779719074 @default.
- W3036162149 hasConcept C2779765511 @default.
- W3036162149 hasConcept C2780559512 @default.
- W3036162149 hasConcept C48349386 @default.
- W3036162149 hasConcept C55493867 @default.
- W3036162149 hasConcept C71924100 @default.