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- W3036164024 abstract "Significance Disruption of memories of stressful events may trigger maladaptive responses that are distinctive features of obsessive-compulsive disorders, phobias, posttraumatic stress disorder (PTSD), and generalized anxiety. Drugs available to alleviate these disorders have minimal or inconsistent efficacy. The gold standard treatment, exposure therapy, is based on extinction, which refers to a new memory trace inhibiting original memory retrieval. As not all patients experience beneficial effects of this therapy, drugs potentiating extinction are of utmost importance for improving treatment. Carbonic anhydrases (CAs) are involved in several physiological processes, including memory. The present study indicates that their activation potentiates extinction. Thus, CA activators may have the potential to improve the clinical efficacy of exposure-based treatments of obsessive-compulsive disorders, phobias, generalized anxiety, and PTSD." @default.
- W3036164024 created "2020-06-25" @default.
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- W3036164024 date "2020-06-22" @default.
- W3036164024 modified "2023-10-18" @default.
- W3036164024 title "The role of carbonic anhydrases in extinction of contextual fear memory" @default.
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- W3036164024 doi "https://doi.org/10.1073/pnas.1910690117" @default.
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